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ICA-069673

Name: ICA-069673
Brand: TargetMol
SKU: T3959
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3959Cas No. 582323-16-8

Alias ICA069673

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

ICA-069673

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Purity: 99.68%

Catalog No. T3959Alias ICA069673Cas No. 582323-16-8

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

Pack Size	Price	Availability
10 mg	$48	In Stock
25 mg	$107	In Stock
50 mg	$191	In Stock
100 mg	$278	In Stock
200 mg	$403	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock

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Purity:99.68%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
Targets&IC50	KCNQ2/Q3:0.69 μM
In vitro	ICA-069673 is 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5. It has no inhibitory against a panel of cardiac ion channels (IC50> 30 μM for hERG, Nav1.5, L type channels, and KCNQ1). ICA-069673 (10 μM) has no activity on GABA(A) gated channels. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, a 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3.
Synonyms	ICA069673

Chemical Properties

Molecular Weight	269.63
Formula	C₁₁H₆ClF₂N₃O
Cas No.	582323-16-8
Smiles	Fc1ccc(cc1F)C(=O)Nc1cnc(Cl)nc1
Relative Density.	1.539 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (185.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7088 mL	18.5439 mL	37.0879 mL	185.4393 mL
5 mM	0.7418 mL	3.7088 mL	7.4176 mL	37.0879 mL
10 mM	0.3709 mL	1.8544 mL	3.7088 mL	18.5439 mL
20 mM	0.1854 mL	0.9272 mL	1.8544 mL	9.2720 mL
50 mM	0.0742 mL	0.3709 mL	0.7418 mL	3.7088 mL
100 mM	0.0371 mL	0.1854 mL	0.3709 mL	1.8544 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc