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ICA-069673

Name: ICA-069673
Brand: TargetMol
SKU: T3959
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3959Cas No. 582323-16-8

Alias ICA069673

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

ICA-069673

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Purity: 99.68%

Catalog No. T3959Alias ICA069673Cas No. 582323-16-8

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$48	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$191	In Stock	In Stock
100 mg	$278	In Stock	In Stock
200 mg	$403	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.68%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
Targets&IC50	KCNQ2/Q3:0.69 μM
In vitro	ICA-069673 is 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5. It has no inhibitory against a panel of cardiac ion channels (IC50> 30 μM for hERG, Nav1.5, L type channels, and KCNQ1). ICA-069673 (10 μM) has no activity on GABA(A) gated channels. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, a 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3.
Synonyms	ICA069673

Chemical Properties

Molecular Weight	269.63
Formula	C₁₁H₆ClF₂N₃O
Cas No.	582323-16-8
Smiles	Fc1ccc(cc1F)C(=O)Nc1cnc(Cl)nc1
Relative Density.	1.539 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (185.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7088 mL	18.5439 mL	37.0879 mL	185.4393 mL
5 mM	0.7418 mL	3.7088 mL	7.4176 mL	37.0879 mL
10 mM	0.3709 mL	1.8544 mL	3.7088 mL	18.5439 mL
20 mM	0.1854 mL	0.9272 mL	1.8544 mL	9.2720 mL
50 mM	0.0742 mL	0.3709 mL	0.7418 mL	3.7088 mL
100 mM	0.0371 mL	0.1854 mL	0.3709 mL	1.8544 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc