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Urolithin C

Name: Urolithin C
Brand: TargetMol
SKU: TN7108
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7108Cas No. 165393-06-6

Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.

Urolithin C

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Purity: 99.53%

Catalog No. TN7108Cas No. 165393-06-6

Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.

Pack Size	Price	Availability
5 mg	$48	In Stock
10 mg	$80	In Stock
25 mg	$146	In Stock
50 mg	$247	In Stock
100 mg	$372	In Stock
200 mg	$549	In Stock
500 mg	$869	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Purity:99.53%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
In vitro	Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells[2]. Urolithin C stimulates reactive oxygen species (ROS) formation[2].
In vivo	In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg)[3].

Chemical Properties

Molecular Weight	244.2
Formula	C₁₃H₈O₅
Cas No.	165393-06-6
Smiles	Oc1ccc2c(c1)oc(=O)c1cc(O)c(O)cc21
Relative Density.	1.640 g/cm3 (Predicted)
Color	Brown
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (204.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0950 mL	20.4750 mL	40.9500 mL	204.7502 mL
5 mM	0.8190 mL	4.0950 mL	8.1900 mL	40.9500 mL
10 mM	0.4095 mL	2.0475 mL	4.0950 mL	20.4750 mL
20 mM	0.2048 mL	1.0238 mL	2.0475 mL	10.2375 mL
50 mM	0.0819 mL	0.4095 mL	0.8190 mL	4.0950 mL
100 mM	0.0410 mL	0.2048 mL	0.4095 mL	2.0475 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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