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2′-O-Methylcytidine

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Catalog No. T38237Cas No. 2140-72-9

2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate. 2′-O-Methylcytidine inhibits HCV RNA replication.

2′-O-Methylcytidine

2′-O-Methylcytidine

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Purity: 99.72%
Catalog No. T38237Cas No. 2140-72-9
2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate. 2′-O-Methylcytidine inhibits HCV RNA replication.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$30In StockIn Stock
500 mg$40In StockIn Stock
1 g$58In StockIn Stock
2 g$83In Stock-
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.72%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

2′-O-Methylcytidine AI Summary
2′-O-Methylcytidine shows bioactivity related to hepatitis C virus (HCV) replication and metabolism. It effectively inhibits NS5B-mediated RNA synthesis in HBI10A cells with an IC50 value of 1200.0 nM and demonstrates antiviral activity against HCV in Huh7 AVA5 cells, achieving an EC50 value of 1800.0 nM. The compound also exhibits cytotoxicity in Huh7 AVA5 cells with a CC50 value greater than 300,000.0 nM. Its metabolic activity varies across different cell types and incubation periods, with different levels of intracellular metabolism observed in Huh-7 and HBI10A cells after 3 hours and 23 hours of incubation..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate. 2′-O-Methylcytidine inhibits HCV RNA replication.
Chemical Properties
Molecular Weight257.24
FormulaC10H15N3O5
Cas No.2140-72-9
SmilesCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(N)nc1=O
Relative Density.1.68 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
PBS (pH 7.2): 10 mg/mL (38.87 mM), Sonication is recommended.
H2O: 62.5 mg/mL (242.96 mM), Sonication is recommended.
DMSO: 0.2 mg/mL (0.78 mM), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RNA synthesisNucleosideAntimetaboliteNucleoside Antimetabolite/AnalogNucleoside AntimetabolitenucleosideInhibitorinhibitHepatitis C virusHCVProteaseHCV replicationHCV ProteaseHCVAnalog2′-O-Methylcytidine2′OMethylcytidine2′ O Methylcytidine
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