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Azadiradione

Name: Azadiradione
Brand: TargetMol
SKU: TN6729
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6729Cas No. 26241-51-0

Alias AZD

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

Azadiradione

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Purity: 99.52%

Catalog No. TN6729Alias AZDCas No. 26241-51-0

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$133	In Stock	In Stock
5 mg	$302	In Stock	In Stock
10 mg	$543	In Stock	In Stock
25 mg	$817	In Stock	In Stock
50 mg	$1,130	-	In Stock
100 mg	$1,530	-	In Stock
1 mL x 10 mM (in DMSO)	$372	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica
In vitro	Azadiradione (AZD)?ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent.?All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes.?Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function.?Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity.?These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide[1].
Synonyms	AZD

Chemical Properties

Molecular Weight	450.57
Formula	C₂₈H₃₄O₅
Cas No.	26241-51-0
Smiles	C[C@]12C=3[C@](C)([C@@H](C(=O)C3)C=4C=COC4)CC[C@@]1([C@]5(C)[C@@](C[C@H]2OC(C)=O)(C(C)(C)C(=O)C=C5)[H])[H]
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (122.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2194 mL	11.0971 mL	22.1941 mL	110.9705 mL
5 mM	0.4439 mL	2.2194 mL	4.4388 mL	22.1941 mL
10 mM	0.2219 mL	1.1097 mL	2.2194 mL	11.0971 mL
20 mM	0.1110 mL	0.5549 mL	1.1097 mL	5.5485 mL
50 mM	0.0444 mL	0.2219 mL	0.4439 mL	2.2194 mL
100 mM	0.0222 mL	0.1110 mL	0.2219 mL	1.1097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc