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Anti-Coagulation factor XIII B/F13B Antibody (9G131) is a Rabbit antibody targeting Coagulation factor XIII B/F13B. Anti-Coagulation factor XIII B/F13B Antibody (9G131) can be used in ELISA,ELISA(Cap).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $92 | 7-10 days | |
100 μL | $270 | 7-10 days |
Description | Anti-Coagulation factor XIII B/F13B Antibody (9G131) is a Rabbit antibody targeting Coagulation factor XIII B/F13B. Anti-Coagulation factor XIII B/F13B Antibody (9G131) can be used in ELISA,ELISA(Cap). |
Alias | FXIIIB, coagulation factor XIII, B polypeptide, Coagulation factor XIII, Coagulation factor 13 |
Ig Type | Monoclonal Rabbit IgG |
Clone | 9G131 |
Reactivity | Human |
Application | ELISA,ELISA(Cap) |
Recommended Dose | ELISA: 1:5000-1:10000; ELISA(Cap): 1:250-1:2000 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor XIII B chain / F13B (rh Coagulation Factor XIII B chain / F13B; TMPY-02185; P05160; Met1-Thr661). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Factor XIII acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Defects in F13B are the cause of factor XIII subunit B deficiency ( FA13BD ) which is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human Coagulation Factor XIII B chain / F13B Protein (TMPY-02185) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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