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Ononin

Name: Ononin
Brand: TargetMol
SKU: T6S0270
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S0270Cas No. 486-62-4

Alias Ononoside, Formononetin glucoside, Formononetin 7-O-β-D-glucopyranoside, Formononetin 7-O-glucoside

1. Ononin (Formononetin 7-O-glucoside) can inhibit the growth of pathogen. 2. Ononin plays an important role in human nutrition as health promoting natural chemicals and are established to be the beneficial components.

Ononin

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Purity: 99.92%

Catalog No. T6S0270Alias Ononoside, Formononetin glucoside, Formononetin 7-O-β-D-glucopyranoside, Formononetin 7-O-glucosideCas No. 486-62-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$147	In Stock	In Stock
50 mg	$215	-	In Stock
100 mg	$318	-	In Stock
200 mg	$469	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Ononin AI Summary

Ononin exhibits a wide range of bioactivities affecting various pathways and targets. It is an inhibitor of hamster liver aldehyde dehydrogenase ALDH-2 with an IC50 greater than 6000 nM and inhibits TPA-stimulated [32P] incorporation into phospholipids in human HeLa cells by 12.3% at 50 µM. The compound also demonstrates significant antiviral properties, including inhibition of EBV-early antigen activation and SARS-CoV-2-related cytotoxicity in human cell lines. Notably, it shows bioactivity against the Spanish flu neuraminidase at 200 µM and inhibits SARS-CoV-2 3CL-Pro protease by 16.26% at 20 µM. Further, Ononin exhibits antimicrobial activity against beta-hemolytic Streptococcus isolate 48 with an MIC of 25 µg/mL. It has demonstrated inhibitory effects on several enzymes including human recombinant aldose reductase (52.3% inhibition), alpha-glucosidase (with an IC50 of 422890 nM), and MMP9 in human U2OS cells at a concentration of 5 µM. The compound displays binding affinities to Bcl-xL and IL-2 with Kd values of 170 nM and 120 nM, respectively, and exhibits anticancer activity against human HepG2 cells with an IC50 of 40800 nM. Additionally, Ononin shows reduction of Fe3+ to Fe2+, scavenging of ABTS and DPPH radicals, indicating significant antioxidant activities. Ononin also modulates miRNAs, activates Rab9 and NPC1 promoter activities, inhibits Nrf2, and shows actions related to DNA repair and genotoxicity in HEK293T cells. It inhibits ELG1-dependent DNA repair and cell surface uPA generation, activates BRCA1 expression, and shows potency against the malarial parasite plastid and Foot and Mouth Disease Virus. Overall, Ononin demonstrates potential therapeutic implications across anticancer, antiviral, antimicrobial, and enzyme inhibition domains, highlighting its broad-spectrum bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Ononin (Formononetin 7-O-glucoside) can inhibit the growth of pathogen. 2. Ononin plays an important role in human nutrition as health promoting natural chemicals and are established to be the beneficial components.
Synonyms	Ononoside, Formononetin glucoside, Formononetin 7-O-β-D-glucopyranoside, Formononetin 7-O-glucoside

Chemical Properties

Molecular Weight	430.40
Formula	C₂₂H₂₂O₉
Cas No.	486-62-4
Smiles	COc1ccc(cc1)-c1coc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2c1=O
Relative Density.	1.482g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55.00 mg/mL (127.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (4.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3234 mL	11.6171 mL	23.2342 mL	116.1710 mL
5 mM	0.4647 mL	2.3234 mL	4.6468 mL	23.2342 mL
10 mM	0.2323 mL	1.1617 mL	2.3234 mL	11.6171 mL
20 mM	0.1162 mL	0.5809 mL	1.1617 mL	5.8086 mL
50 mM	0.0465 mL	0.2323 mL	0.4647 mL	2.3234 mL
100 mM	0.0232 mL	0.1162 mL	0.2323 mL	1.1617 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc