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Chelidamic acid

Name: Chelidamic acid
Brand: TargetMol
SKU: T5884
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5884Cas No. 138-60-3

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton and acts as an inhibitor of glutamate decarboxylase, with a Ki of 33 μM.

Chelidamic acid

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Purity: 98.11%

Catalog No. T5884Cas No. 138-60-3

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton and acts as an inhibitor of glutamate decarboxylase, with a Ki of 33 μM.

Pack Size	Price	Availability
500 mg	$32	In Stock
1 g	$46	In Stock
2 g	$66	In Stock

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Purity:98.11%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Chelidamic acid is a heterocyclic organic acid with a pyran skeleton and acts as an inhibitor of glutamate decarboxylase, with a Ki of 33 μM.
Targets&IC50	Glutamate decarboxylase (GAD):33 μM (Ki)
In vitro	Chelidonic acid inhibited the glutamate-dependent formation of apoenzyme. Chelidonic acid itself did not promote formation of apoenzyme and did not react with free pyridoxal-P.Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM[1].

Chemical Properties

Molecular Weight	183.12
Formula	C₇H₅NO₅
Cas No.	138-60-3
Smiles	C(O)(=O)C=1NC(C(O)=O)=CC(=O)C1
Relative Density.	1.726 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (327.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4609 mL	27.3045 mL	54.6090 mL	273.0450 mL
5 mM	1.0922 mL	5.4609 mL	10.9218 mL	54.6090 mL
10 mM	0.5461 mL	2.7304 mL	5.4609 mL	27.3045 mL
20 mM	0.2730 mL	1.3652 mL	2.7304 mL	13.6522 mL
50 mM	0.1092 mL	0.5461 mL	1.0922 mL	5.4609 mL
100 mM	0.0546 mL	0.2730 mL	0.5461 mL	2.7304 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc