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Anti-Cyclophilin A Antibody (4R688)
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Catalog No. TMAH-00998
Alias peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA
Anti-Cyclophilin A Antibody (4R688) is an antibody targeting Cyclophilin A. Anti-Cyclophilin A Antibody (4R688) can be used in ELISA,WB.
Anti-Cyclophilin A Antibody (4R688)
Anti-Cyclophilin A Antibody (4R688)
😃Good
Catalog No. TMAH-00998Alias peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA
Anti-Cyclophilin A Antibody (4R688) is an antibody targeting Cyclophilin A. Anti-Cyclophilin A Antibody (4R688) can be used in ELISA,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Cyclophilin A Antibody (4R688) is an antibody targeting Cyclophilin A. Anti-Cyclophilin A Antibody (4R688) can be used in ELISA,WB. |
| Synonyms | peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA |
| Ig Type | Rabbit IgG |
| Clone | 4R688 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Raji whole cell lysate, HepG2 whole cell lysate -All lanes: Cyclophilin A antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 19, 12 kDa -Observed band size: 19 kDa |
| Application | |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Secreted. Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans. Inhibits replication of influenza A virus (IAV). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV. (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus. (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Cyclophilin A |
| Antigen Species | Human |
| Gene Name | PPIA |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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