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Anti-CUEDC2 Antibody (4L751)
😃Good
Catalog No. TMAY-01868
Alias MGC2491, HOYS6, CUEDC 2, C10orf66, bA18I14.5
Anti-CUEDC2 Antibody (4L751) is a Mouse antibody targeting CUEDC2. Anti-CUEDC2 Antibody (4L751) can be used in FCM.
Anti-CUEDC2 Antibody (4L751)
Anti-CUEDC2 Antibody (4L751)
😃Good
Catalog No. TMAY-01868Alias MGC2491, HOYS6, CUEDC 2, C10orf66, bA18I14.5
Anti-CUEDC2 Antibody (4L751) is a Mouse antibody targeting CUEDC2. Anti-CUEDC2 Antibody (4L751) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CUEDC2 Antibody (4L751) is a Mouse antibody targeting CUEDC2. Anti-CUEDC2 Antibody (4L751) can be used in FCM. |
| Alias | MGC2491, HOYS6, CUEDC 2, C10orf66, bA18I14.5 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4L751 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CUEDC2 expression on SHSY5Y cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human CUEDC2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibition. CUEDC2 is also known to interact with IkB kinase alpha (IKKalpha) and IKKbeta and has an inhibitory role in the activation of transcription factor nuclear factor-kappaB. Moreover, CUEDC2 plays an important role in downregulating the expression of hormone receptors estrogen receptor-alpha and progesterone receptor, thereby impairing the responsiveness of breast cancer to endocrine therapies. The expression level of CUEDC2 has an inverse correlation with imatinib resistance and activity of NF-kappaB signaling pathway in CML cells, CUEDC2 could regulate imatinib sensitivity in CML cells at least partially through NF-kappaB signaling pathway. CUEDC2 may be a promising biomarker to evaluate the progression of serous ovarian carcinoma and to predict likely relapse of ovarian serous carcinoma. The decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CUEDC2 Protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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