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ATX inhibitor 11

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Synonyms:

Catalog No. T64141 Copy Product Info

Purity: 99.96%

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ATX inhibitor 11 is a potent inhibitor of autotaxin (ATX) with an IC50 of 2.7 nM. ATX inhibitor 11 reduces fibrosis severity and decreases α-SMA deposition in mouse models of fibrosis. ATX inhibitor 11 is utilized in fibrosis-related research focused on lysophosphatidic acid signaling, extracellular matrix remodeling, and fibroblast activation mechanisms in pulmonary and tissue fibrosis models.

Cas No. 2485779-27-7

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Pack Size	Price	USA Stock	Global Stock
1 mg	$88	-	In Stock
5 mg	$213	-	In Stock
10 mg	$339	-	In Stock
25 mg	$683	-	In Stock
50 mg	$1,090	-	In Stock
100 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$276	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	ATX inhibitor 11 is a potent inhibitor of autotaxin (ATX) with an IC50 of 2.7 nM. ATX inhibitor 11 reduces fibrosis severity and decreases α-SMA deposition in mouse models of fibrosis. ATX inhibitor 11 is utilized in fibrosis-related research focused on lysophosphatidic acid signaling, extracellular matrix remodeling, and fibroblast activation mechanisms in pulmonary and tissue fibrosis models.
Targets & IC50	ATX:2.7 ± 1 nM

Chemical Properties

Molecular Weight	585.65
Formula	C₃₂H₃₅N₅O₆
Cas No.	2485779-27-7
Smiles	O=C(OCC1=CC=C2OCOC2=C1)NC3=C(N=C4C(=CC(=CN43)C=5C=CC(=CC5)C(=O)N6CCN(CCO)CC6)C)CC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (136.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7075 mL	8.5375 mL	17.0750 mL	85.3752 mL
5 mM	0.3415 mL	1.7075 mL	3.4150 mL	17.0750 mL
10 mM	0.1708 mL	0.8538 mL	1.7075 mL	8.5375 mL
20 mM	0.0854 mL	0.4269 mL	0.8538 mL	4.2688 mL
50 mM	0.0342 mL	0.1708 mL	0.3415 mL	1.7075 mL
100 mM	0.0171 mL	0.0854 mL	0.1708 mL	0.8538 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: ATX inhibitor 11 chemical structure | ATX inhibitor 11 formula | ATX inhibitor 11 molecular weight