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Phosalone

Name: Phosalone
Brand: TargetMol
SKU: T5839
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5839Cas No. 2310-17-0

Phosalone is an organophosphate chemical commonly used as an insecticide and acaricide.

Phosalone

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Purity: 98.45%

Catalog No. T5839Cas No. 2310-17-0

Phosalone is an organophosphate chemical commonly used as an insecticide and acaricide.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.45%

Appearance:Solid

Color:White to Red

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Phosalone is an organophosphate chemical commonly used as an insecticide and acaricide.

In vivo

Phosalone (PLN) as a key member of OPs, to induce senescence in rat embryonic fibroblast (REF) cells and to demonstrate the beneficial effects of the known antioxidant ellagic acid (EA) in diminishing the PLN-induced toxic effects, the levels of cell viability, oxidative stress markers, inflammatory cytokines, telomerase activity, and the expression of the genes related to senescence were investigated. This accounts for the mechanistic approval of the role of OPs in induction of senescence in rat fibroblasts. Incorporation of EA diminished PLN toxicity mainly through suppression of p38 and p53 at gene and protein levels, and tempered the inflammation factors (TNF-α, IL-1β, IL-6 and NF-κB), which further affected cell division.

Chemical Properties

Molecular Weight	367.81
Formula	C₁₂H₁₅ClNO₄PS₂
Cas No.	2310-17-0
Smiles	C(SP(OCC)(OCC)=S)N1C=2C(OC1=O)=CC(Cl)=CC2
Relative Density.	1.39 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (135.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7188 mL	13.5940 mL	27.1880 mL	135.9398 mL
5 mM	0.5438 mL	2.7188 mL	5.4376 mL	27.1880 mL
10 mM	0.2719 mL	1.3594 mL	2.7188 mL	13.5940 mL
20 mM	0.1359 mL	0.6797 mL	1.3594 mL	6.7970 mL
50 mM	0.0544 mL	0.2719 mL	0.5438 mL	2.7188 mL
100 mM	0.0272 mL	0.1359 mL	0.2719 mL	1.3594 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc