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O-304

Name: O-304
Brand: TargetMol
SKU: T7362
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T7362Cas No. 1261289-04-6

O-304 is a pan-activator of AMP-activated protein kinase (AMPK).

O-304

😃Good

Purity: 99.84%

Catalog No. T7362Cas No. 1261289-04-6

O-304 is a pan-activator of AMP-activated protein kinase (AMPK).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$60	In Stock	In Stock
2 mg	$88	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$455	In Stock	In Stock
50 mg	$672	In Stock	In Stock
100 mg	$956	In Stock	In Stock
500 mg	$1,920	-	In Stock
1 mL x 10 mM (in DMSO)	$162	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.84%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
In vivo	In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.

Chemical Properties

Molecular Weight	380.25
Formula	C₁₆H₁₁Cl₂N₃O₂S
Cas No.	1261289-04-6
Smiles	Clc1ccc(Cn2sc(NC(=O)c3ccc(Cl)cc3)nc2=O)cc1
Relative Density.	1.50 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (118.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.26 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6298 mL	13.1492 mL	26.2985 mL	131.4924 mL
5 mM	0.5260 mL	2.6298 mL	5.2597 mL	26.2985 mL
10 mM	0.2630 mL	1.3149 mL	2.6298 mL	13.1492 mL
20 mM	0.1315 mL	0.6575 mL	1.3149 mL	6.5746 mL
50 mM	0.0526 mL	0.2630 mL	0.5260 mL	2.6298 mL
100 mM	0.0263 mL	0.1315 mL	0.2630 mL	1.3149 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc