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Drozitumab
(Synonyms: rhuMAb-DR 5, RG7425, RG 7425, PRO95780, PRO 95780, Anti-Human DR5 Recombinant Antibody) Copy Product Info
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Synonyms: rhuMAb-DR 5, RG7425, RG 7425, PRO95780, PRO 95780, Anti-Human DR5 Recombinant Antibody
Catalog No. T76802 Copy Product Info
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Drozitumab (PRO 95780) is a fully humanized antibody targeting the death receptor DR5 that shows anti-tumor activity against rhabdomyosarcoma, binds to the death receptor DR5 and induces apoptosis, and can be used in the study of triple-negative breast cancer.
Cas No. 912628-39-8
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $197 | In Stock | In Stock | |
| 5 mg | $596 | In Stock | In Stock | |
| 10 mg | $959 | - | In Stock | |
| 25 mg | $1,420 | - | In Stock | |
| 50 mg | $1,920 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.2% (SDS-PAGE); 98.9% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
Antibody Information
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| Description | Drozitumab (PRO 95780) is a fully humanized antibody targeting the death receptor DR5 that shows anti-tumor activity against rhabdomyosarcoma, binds to the death receptor DR5 and induces apoptosis, and can be used in the study of triple-negative breast cancer. |
| In vitro | Drozitumab is able to target and remove cancer stem cells (CSCs), thereby stopping tumor growth and potentially shrinking or even regressing pancreatic tumors. [3] Drozitumab caused apoptosis in mesenchymal TNBC cell lines, but did not show the same effect in other subtypes of breast cancer cell lines. [1] |
| Synonyms | rhuMAb-DR 5, RG7425, RG 7425, PRO95780, PRO 95780, Anti-Human DR5 Recombinant Antibody |
| Reactivity | Human |
| Verified Activity | Immobilized Human DR5/TRAIL R2 Protein (His) (TMPY-01185) at 1 μg/mL (100 μL/well) can bind Drozitumab. The EC50 is 1.93 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF10B/TRAILR2/CD262 |
| Molecular Weight | 143.09 kDa |
| Cas No. | 912628-39-8 |
| Isotype | IgG1 |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Drozitumab chemical structure | Drozitumab in vitro | Drozitumab molecular weight
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