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Indole-3-carboxylic acid

Name: Indole-3-carboxylic acid
Brand: TargetMol
SKU: T5984
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5984Cas No. 771-50-6

Alias 3-Indoleformic acid

Indole-3-carboxylic acid (3-Indoleformic acid) is a normal urinary indolic tryptophan metabolite .

Indole-3-carboxylic acid

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Purity: 99.81%

Catalog No. T5984Alias 3-Indoleformic acidCas No. 771-50-6

Indole-3-carboxylic acid (3-Indoleformic acid) is a normal urinary indolic tryptophan metabolite .

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$31	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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Product Introduction

Indole-3-carboxylic acid AI Summary

Indole-3-carboxylic acid exhibits a range of biological and chemical properties, indicating its potential for various pharmacological applications. It shows a high permeability coefficient through an artificial membrane and good solubility with an apparent LogP value of -6.1 and a partition coefficient (log P) of 1.99. Notably, Indole-3-carboxylic acid inhibits the SRC2-3 interaction with the androgen receptor ligand binding domain, with an inhibition rate of 1.0% at a concentration of 50 µM after 2 hours, as determined using a fluorescence polarization assay. It also demonstrates significant antioxidant activity, such as trolox equivalent ABTS radical scavenging activity with a TEAC value of 0.092 and beta-carotene bleaching inhibition levels of -10.1 and -6.5 at 60 mins and 120 mins, respectively. In terms of anti-inflammatory properties, Indole-3-carboxylic acid has shown moderate potency in reducing LPS-induced NO production in mouse RAW264.7 cells, with an IC50 value greater than 10,000 nanometers. Additionally, it reveals antifungal activity against Candida albicans ATCC 90028 (6.48% inhibition) and Cryptococcus neoformans H99 ATCC 208821 (-9.05% inhibition), as well as varied antibacterial activity against several bacterial strains, including a notable inhibition of Pseudomonas aeruginosa ATCC 27853 (16.88% inhibition). Furthermore, the dissociation constant of Indole-3-carboxylic acid, determined via dip probe absorption spectroscopy, yields a pKa value of 5.29, providing insights into its dissociation behavior in aqueous solutions and potential bioactivity. Overall, these comprehensive bioactivities make Indole-3-carboxylic acid a compound of interest for further pharmacological studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Indole-3-carboxylic acid (3-Indoleformic acid) is a normal urinary indolic tryptophan metabolite .
Synonyms	3-Indoleformic acid

Chemical Properties

Molecular Weight	161.16
Formula	C₉H₇NO₂
Cas No.	771-50-6
Smiles	OC(=O)C1=CNC2=CC=CC=C12
Relative Density.	1.2480 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (1504.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2050 mL	31.0251 mL	62.0501 mL	310.2507 mL
5 mM	1.2410 mL	6.2050 mL	12.4100 mL	62.0501 mL
10 mM	0.6205 mL	3.1025 mL	6.2050 mL	31.0251 mL
20 mM	0.3103 mL	1.5513 mL	3.1025 mL	15.5125 mL
50 mM	0.1241 mL	0.6205 mL	1.2410 mL	6.2050 mL
100 mM	0.0621 mL	0.3103 mL	0.6205 mL	3.1025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc