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H-Tyr(3-I)-OH

Name: H-Tyr(3-I)-OH
Brand: TargetMol
SKU: T5568
Rating: 4.5 (1 reviews)

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Catalog No. T5568Cas No. 70-78-0

Alias 3-Iodo-L-tyrosine

H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones

H-Tyr(3-I)-OH

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Purity: 99.79%

Catalog No. T5568Alias 3-Iodo-L-tyrosineCas No. 70-78-0

H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	Inquiry	Inquiry

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones
In vivo	3-iodo-L-tyrosine, at high concentration, is able to induce the intracellular aggregation of αSyn, and death of TH-positive neurons. These phenomena are considered as hallmarks of PD
Animal Research	Twenty mice were infused with H-Tyr(3-I)-OH into the dorsal striata.?Mice were anesthetized with ketamine (50 mg/kg IP) and xylazine (5mg/kg IP,) and placed in a David Kopf stereotaxic apparatus.?Vehicle and H-Tyr(3-I)-OH solution (0, 1 and 10μM H-Tyr(3-I)-OH dissolved in 0.9% NaCl with 0.001% acetic acid) was slowly injected (5 μl volume) with a blunted 30-gauge cannula at the following coordinates of the left dorsal striata with respect to bregma: AP= +0.86, L= +1.6, and V= -3.5 mm.
Synonyms	3-Iodo-L-tyrosine

Chemical Properties

Molecular Weight	307.09
Formula	C₉H₁₀INO₃
Cas No.	70-78-0
Smiles	C([C@@H](C(O)=O)N)C1=CC(I)=C(O)C=C1
Relative Density.	1.944 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mM, Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.2564 mL	16.2819 mL	32.5637 mL	162.8187 mL
5 mM	0.6513 mL	3.2564 mL	6.5127 mL	32.5637 mL
10 mM	0.3256 mL	1.6282 mL	3.2564 mL	16.2819 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc