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L755507

Name: L755507
Brand: TargetMol
SKU: T6872
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6872Cas No. 159182-43-1

L755507 is an effective, selective agonist of β3-AR(IC50=35 nM).

L755507

🥰Excellent

Purity: 99.75%

Catalog No. T6872Cas No. 159182-43-1

L755507 is an effective, selective agonist of β3-AR(IC50=35 nM).

Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$109	In Stock
10 mg	$176	In Stock
25 mg	$313	In Stock
50 mg	$468	In Stock
100 mg	$673	In Stock
1 mL x 10 mM (in DMSO)	$142	In Stock

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Purity:99.75%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	L755507 is an effective, selective agonist of β3-AR(IC50=35 nM).
Targets&IC50	β3-adrenoceptor:35 nM
In vitro	L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3].
In vivo	Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2].

Chemical Properties

Molecular Weight	584.73
Formula	C₃₀H₄₀N₄O₆S
Cas No.	159182-43-1
Smiles	CCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1
Relative Density.	1.274g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (68.41 mM), Sonication is recommended.

Ethanol: 58.5 mg/mL (100.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.7102 mL	8.5510 mL	17.1019 mL	85.5096 mL
5 mM	0.3420 mL	1.7102 mL	3.4204 mL	17.1019 mL
10 mM	0.1710 mL	0.8551 mL	1.7102 mL	8.5510 mL
20 mM	0.0855 mL	0.4275 mL	0.8551 mL	4.2755 mL
50 mM	0.0342 mL	0.1710 mL	0.3420 mL	1.7102 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0171 mL	0.0855 mL	0.1710 mL	0.8551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc