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Anti-RPE65 Antibody (2C823)
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Catalog No. TMAH-01051
Anti-RPE65 Antibody (2C823) is an antibody targeting RPE65. Anti-RPE65 Antibody (2C823) can be used in ELISA,IHC.
Anti-RPE65 Antibody (2C823)
Anti-RPE65 Antibody (2C823)
😃Good
Catalog No. TMAH-01051
Anti-RPE65 Antibody (2C823) is an antibody targeting RPE65. Anti-RPE65 Antibody (2C823) can be used in ELISA,IHC.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-RPE65 Antibody (2C823) is an antibody targeting RPE65. Anti-RPE65 Antibody (2C823) can be used in ELISA,IHC. |
| Ig Type | Rabbit IgG |
| Clone | 2C823 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-01051 diluted at 1:100 and staining in paraffin-embedded human eye tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Cell membrane; Lipid-anchor. Microsome membrane. |
| Tissue Specificity | Retina (at protein level). Retinal pigment epithelium specific. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human RPE65 |
| Antigen Species | Human |
| Gene Name | RPE65 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Neuroscience, Cancer, Tags & Cell Markers, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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