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Emodin 6-O-β-D-glucoside

🥰Excellent
Catalog No. TN6774Cas No. 34298-85-6
Alias Glucoemodin

Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Emodin 6-O-β-D-glucoside

Emodin 6-O-β-D-glucoside

🥰Excellent
Purity: 97.61%
Catalog No. TN6774Alias GlucoemodinCas No. 34298-85-6
Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.
Pack SizePriceAvailabilityQuantity
1 mg$73In Stock
5 mg$179In Stock
10 mg$289In Stock
25 mg$489In Stock
1 mL x 10 mM (in DMSO)$212In Stock
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Purity:97.61%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.
In vitro
Emodin-6-O-β-D-glucoside (EG), a novel active compound from Reynoutria japonica, suppresses HMGB1 release, TNF-α production, and HMGB1-induced NF-κB activation in HUVECs.
In vivo
Emodin-6-O-β-D-glucoside (EG) inhibits HMGB1-mediated hyperpermeability and leukocyte migration in mice, and increases the survival times of CLP-administered mice.
SynonymsGlucoemodin
Chemical Properties
Molecular Weight432.38
FormulaC21H20O10
Cas No.34298-85-6
SmilesCc1cc(O)c2C(=O)c3c(O)cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3C(=O)c2c1
Relative Density.1.667 g/cm3 (Predicted)
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 65 mg/mL (150.33 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3128 mL11.5639 mL23.1278 mL115.6390 mL
5 mM0.4626 mL2.3128 mL4.6256 mL23.1278 mL
10 mM0.2313 mL1.1564 mL2.3128 mL11.5639 mL
20 mM0.1156 mL0.5782 mL1.1564 mL5.7820 mL
50 mM0.0463 mL0.2313 mL0.4626 mL2.3128 mL
100 mM0.0231 mL0.1156 mL0.2313 mL1.1564 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

ReynoutriaprotectivepotentjaponicaInhibitorinhibitEmodin 6-O-β-D-glucosideEmodin 6OβDglucosideEmodin 6-O-beta-D-glucosideEmodin 6-O-b-D-glucosideEmodin 6 O β D glucosidediabeticcomplicationsbarrieratherosclerosisanti-inflammatoryactive
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