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Emodin 6-O-β-D-glucoside

Name: Emodin 6-O-β-D-glucoside
Brand: TargetMol
SKU: TN6774
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN6774Cas No. 34298-85-6

Alias Glucoemodin

Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Emodin 6-O-β-D-glucoside

🥰Excellent

Purity: 98.06%

Catalog No. TN6774Alias GlucoemodinCas No. 34298-85-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
5 mg	$179	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$489	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$212	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.06%

Color:Transparent to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.
In vitro	Emodin-6-O-β-D-glucoside (EG), a novel active compound from Reynoutria japonica, suppresses HMGB1 release, TNF-α production, and HMGB1-induced NF-κB activation in HUVECs.
In vivo	Emodin-6-O-β-D-glucoside (EG) inhibits HMGB1-mediated hyperpermeability and leukocyte migration in mice, and increases the survival times of CLP-administered mice.
Synonyms	Glucoemodin

Chemical Properties

Molecular Weight	432.38
Formula	C₂₁H₂₀O₁₀
Cas No.	34298-85-6
Smiles	Cc1cc(O)c2C(=O)c3c(O)cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3C(=O)c2c1
Relative Density.	1.667 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (150.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3128 mL	11.5639 mL	23.1278 mL	115.6390 mL
5 mM	0.4626 mL	2.3128 mL	4.6256 mL	23.1278 mL
10 mM	0.2313 mL	1.1564 mL	2.3128 mL	11.5639 mL
20 mM	0.1156 mL	0.5782 mL	1.1564 mL	5.7820 mL
50 mM	0.0463 mL	0.2313 mL	0.4626 mL	2.3128 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	1.1564 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc