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RHC 80267

Name: RHC 80267
Brand: TargetMol
SKU: T8236
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8236Cas No. 83654-05-1

Alias U-57908

RHC 80267 (U-57908) is a selective inhibitor of DAGL, with an IC50 of 4 μM in canine platelets.

RHC 80267

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Purity: 99.54%

Catalog No. T8236Alias U-57908Cas No. 83654-05-1

RHC 80267 (U-57908) is a selective inhibitor of DAGL, with an IC50 of 4 μM in canine platelets.

Pack Size	Price	Availability
5 mg	$31	In Stock
10 mg	$54	In Stock
25 mg	$108	In Stock
50 mg	$179	In Stock
100 mg	$268	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Batch Information

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Purity:99.54%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	RHC 80267 (U-57908) is a selective inhibitor of DAGL, with an IC50 of 4 μM in canine platelets.
Targets&IC50	DAGL:4 µM in canine platelets
In vitro	RHC-80267 is thought to initiate activation of protein kinase C.2?At 0.3-1 μM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation?in vitro
Synonyms	U-57908

Chemical Properties

Molecular Weight	394.51
Formula	C₂₀H₃₄N₄O₄
Cas No.	83654-05-1
Smiles	O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1
Relative Density.	1.21 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (63.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5348 mL	12.6739 mL	25.3479 mL	126.7395 mL
5 mM	0.5070 mL	2.5348 mL	5.0696 mL	25.3479 mL
10 mM	0.2535 mL	1.2674 mL	2.5348 mL	12.6739 mL
20 mM	0.1267 mL	0.6337 mL	1.2674 mL	6.3370 mL
50 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5348 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc