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α-Pyridone

Name: α-Pyridone
Brand: TargetMol
SKU: T4805
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4805Cas No. 142-08-5

Alias 2-Hydroxypyridine

α-Pyridone (2-Hydroxypyridine)e is the catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.

α-Pyridone

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Purity: 99.73%

Catalog No. T4805Alias 2-HydroxypyridineCas No. 142-08-5

α-Pyridone (2-Hydroxypyridine)e is the catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Viscous

Color:White

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COA HNMR HPLC LCMS

Product Introduction

α-Pyridone AI Summary

α-Pyridone exhibits multiple bioactivities and interactions across various systems. It induces erythroid differentiation in murine leukemia cells, with notable increases in benzidine-positive cells: 95.0% in murine erythroleukemia cells and up to 26.0% in DBA/2J mouse Friend erythroleukemia cells after 6 days at concentrations of 16.0 mM and 8.6 mM, respectively. Additionally, it affects cell growth, initially increasing it by 114.0% on day 3 before decreasing to 77.0% on day 6. The compound also exhibits inhibitory activity against murine gelatinase B below 5.0% at a concentration of 5 mM. In the realm of neural binding, α-Pyridone enhances the binding of (+/-)-[3H]nicotine to rat brain P2 fraction at binding sites with Kd values of 880,000.0 nM for site 2 and 160,000,000.0 nM for site 3, achieving a maximum inhibition of 259.0%. Its modulation of nicotine binding was evaluated across a dose range from 10 E -10 to 10 E -4 M. The compound also shows cytotoxicity against human MIA PaCa2 cells with IC50 values of 68137.0 nM after 4 hours and 68804.0 nM after 72 hours, based on MTT assay results. Binding studies reveal its affinity for the 15N-labeled FKBP51 protein, with a dissociation constant (Kd) of 1300000.0 nM, as determined by two-dimensional 1H/15N HSQC NMR spectroscopy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	α-Pyridone (2-Hydroxypyridine)e is the catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.
Synonyms	2-Hydroxypyridine

Chemical Properties

Molecular Weight	95.1
Formula	C₅H₅NO
Cas No.	142-08-5
Smiles	O=C1NC=CC=C1
Relative Density.	1.39

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (105.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (10.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	10.5152 mL	52.5762 mL	105.1525 mL	525.7624 mL
5 mM	2.1030 mL	10.5152 mL	21.0305 mL	105.1525 mL
10 mM	1.0515 mL	5.2576 mL	10.5152 mL	52.5762 mL
20 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
50 mM	0.2103 mL	1.0515 mL	2.1030 mL	10.5152 mL
100 mM	0.1052 mL	0.5258 mL	1.0515 mL	5.2576 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc