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Ilimaquinone

Name: Ilimaquinone
Brand: TargetMol
SKU: T38242
Rating: 4.5 (1 reviews)

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Catalog No. T38242Cas No. 71678-03-0

Ilimaquinone is a natural sesquiterpenoid quinone and sponge metabolite capable of inducing cancer cell apoptosis. It activates cell death factors such as Bcl-2 and Bcl-xL, reduces PDK1 activity, activates p53, and downregulates β-Catenin, among other effects.

Ilimaquinone

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Catalog No. T38242Cas No. 71678-03-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 μg	$499	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Viscous

Color:Yellow

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Product Introduction

Bioactivity

Description	Ilimaquinone is a natural sesquiterpenoid quinone and sponge metabolite capable of inducing cancer cell apoptosis. It activates cell death factors such as Bcl-2 and Bcl-xL, reduces PDK1 activity, activates p53, and downregulates β-Catenin, among other effects.
In vitro	Ilimaquinone exhibits concentration-dependent antiproliferative effects on multiple cancer cell lines, including prostate cancer cells PC-3 and LNCaP, non-small cell lung cancer cells A549, and liver cancer cells Hep3B. At concentrations ranging from 0.3-30 μM with a treatment duration of 48 hours, Ilimaquinone effectively inhibits cell proliferation, with corresponding GI₅₀ values of 2.6 μM (PC-3), 5.8 μM (DU145), 4.6 μM (LNCaP), 4.9 μM (MG63), 4.1 μM (A549), and 12.0 μM (Hep3B) [1].
In vivo	In male SD rats, after oral administration of Ilimaquinone (at a dose of 10 mg/kg), due to its high plasma clearance rate (2.95±0.53 L/h/kg), the drug exhibited a relatively short terminal elimination half-life (T₁/₂ = 1.2±0.3 hours) [2].

Chemical Properties

Molecular Weight	358.48
Formula	C₂₂H₃₀O₄
Cas No.	71678-03-0
Smiles	C([C@@]1(C)[C@]2([C@](C)(CC[C@@H]1C)C(=C)CCC2)[H])C=3C(=O)C(OC)=CC(=O)C3O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Hexane: Soluble

Methanol: Soluble

DMSO: 20 mg/mL (55.79 mM), Sonication is recommended.

Ethanol: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7896 mL	13.9478 mL	27.8956 mL	139.4778 mL
5 mM	0.5579 mL	2.7896 mL	5.5791 mL	27.8956 mL
10 mM	0.2790 mL	1.3948 mL	2.7896 mL	13.9478 mL
20 mM	0.1395 mL	0.6974 mL	1.3948 mL	6.9739 mL
50 mM	0.0558 mL	0.2790 mL	0.5579 mL	2.7896 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc