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Ilimaquinone

Name: Ilimaquinone
Brand: TargetMol
SKU: T38242
Rating: 4.5 (1 reviews)

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Catalog No. T38242Cas No. 71678-03-0

Ilimaquinone is a natural sesquiterpenoid quinone and sponge metabolite capable of inducing cancer cell apoptosis. It activates cell death factors such as Bcl-2 and Bcl-xL, reduces PDK1 activity, activates p53, and downregulates β-Catenin, among other effects.

Ilimaquinone

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Catalog No. T38242Cas No. 71678-03-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 μg	$499	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Ilimaquinone is a natural sesquiterpenoid quinone and sponge metabolite capable of inducing cancer cell apoptosis. It activates cell death factors such as Bcl-2 and Bcl-xL, reduces PDK1 activity, activates p53, and downregulates β-Catenin, among other effects.
In vitro	Ilimaquinone exhibits concentration-dependent antiproliferative effects on multiple cancer cell lines, including prostate cancer cells PC-3 and LNCaP, non-small cell lung cancer cells A549, and liver cancer cells Hep3B. At concentrations ranging from 0.3-30 μM with a treatment duration of 48 hours, Ilimaquinone effectively inhibits cell proliferation, with corresponding GI₅₀ values of 2.6 μM (PC-3), 5.8 μM (DU145), 4.6 μM (LNCaP), 4.9 μM (MG63), 4.1 μM (A549), and 12.0 μM (Hep3B) [1].
In vivo	In male SD rats, after oral administration of Ilimaquinone (at a dose of 10 mg/kg), due to its high plasma clearance rate (2.95±0.53 L/h/kg), the drug exhibited a relatively short terminal elimination half-life (T₁/₂ = 1.2±0.3 hours) [2].

Chemical Properties

Molecular Weight	358.48
Formula	C₂₂H₃₀O₄
Cas No.	71678-03-0
Smiles	C([C@@]1(C)[C@]2([C@](C)(CC[C@@H]1C)C(=C)CCC2)[H])C=3C(=O)C(OC)=CC(=O)C3O
Color	Yellow
Appearance	Viscous

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Hexane: Soluble

Methanol: Soluble

DMSO: 20.00 mg/mL (55.79 mM), Sonication is recommended.

Ethanol: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7896 mL	13.9478 mL	27.8956 mL	139.4778 mL
5 mM	0.5579 mL	2.7896 mL	5.5791 mL	27.8956 mL
10 mM	0.2790 mL	1.3948 mL	2.7896 mL	13.9478 mL
20 mM	0.1395 mL	0.6974 mL	1.3948 mL	6.9739 mL
50 mM	0.0558 mL	0.2790 mL	0.5579 mL	2.7896 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc