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5'-Fluoroindirubinoxime

Name: 5'-Fluoroindirubinoxime
Brand: TargetMol
SKU: T8317
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8317Cas No. 861214-33-7

Alias 5'-FIO

5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).

5'-Fluoroindirubinoxime

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Catalog No. T8317Alias 5'-FIOCas No. 861214-33-7

5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$428	In Stock	In Stock
100 mg	$623	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).
Targets&IC50	FLT3:15 nM
Synonyms	5'-FIO

Chemical Properties

Molecular Weight	295.27
Formula	C₁₆H₁₀FN₃O₂
Cas No.	861214-33-7
Smiles	O\N=C1\C(\Nc2ccccc\12)=C1/C(=O)Nc2ccc(F)cc12
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (282.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3867 mL	16.9337 mL	33.8673 mL	169.3365 mL
5 mM	0.6773 mL	3.3867 mL	6.7735 mL	33.8673 mL
10 mM	0.3387 mL	1.6934 mL	3.3867 mL	16.9337 mL
20 mM	0.1693 mL	0.8467 mL	1.6934 mL	8.4668 mL
50 mM	0.0677 mL	0.3387 mL	0.6773 mL	3.3867 mL
100 mM	0.0339 mL	0.1693 mL	0.3387 mL	1.6934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc