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Dihydromyricetin

Name: Dihydromyricetin
Brand: TargetMol
SKU: T2998
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2998Cas No. 27200-12-0

Alias Ampeloptin, Ampelopsin

Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.

Dihydromyricetin

🥰Excellent

Purity: 98.229%

Catalog No. T2998Alias Ampeloptin, AmpelopsinCas No. 27200-12-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$139	In Stock	In Stock
500 mg	$346	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.229%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.
Targets&IC50	mTOR:48 μM
In vitro	Intraperitoneal injection of 1 mg/kg Dihydromyricetin in rats neutralizes the symptoms of acute alcohol intoxication and eliminates signs of increased tolerance, heightened anxiety, and susceptibility to convulsions. The LD50 for intraperitoneal injection in mice is 1.41 g/kg.
In vivo	Dihydromyricetin (1 μM), as an innovative anti-alcohol intoxication agent, antagonizes acute ethanol-induced enhancements in GABA(A)Rs, as well as increases in GABA(A)R plasticity and expression of the GABA(A)R α4 subunit in the hippocampus and cultured neurons due to ethanol exposure/withdrawal. Additionally, Dihydromyricetin effectively scavenges DPPH radicals and inhibits the increase in lipid peroxidation catalyzed by FeSO4 and ethylenediaminetetraacetic acid in the linoleic acid system.
Synonyms	Ampeloptin, Ampelopsin

Chemical Properties

Molecular Weight	320.25
Formula	C₁₅H₁₂O₈
Cas No.	27200-12-0
Smiles	O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1cc(O)c(O)c(O)c1
Relative Density.	1.808 g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 60 mg/mL (187.35 mM), Sonication is recommended.

DMSO: 242 mg/mL (755.66 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1226 mL	15.6128 mL	31.2256 mL	156.1280 mL
5 mM	0.6245 mL	3.1226 mL	6.2451 mL	31.2256 mL
10 mM	0.3123 mL	1.5613 mL	3.1226 mL	15.6128 mL
20 mM	0.1561 mL	0.7806 mL	1.5613 mL	7.8064 mL
50 mM	0.0625 mL	0.3123 mL	0.6245 mL	3.1226 mL
100 mM	0.0312 mL	0.1561 mL	0.3123 mL	1.5613 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc