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Dihydromyricetin

Name: Dihydromyricetin
Brand: TargetMol
SKU: T2998
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2998Cas No. 27200-12-0

Alias Ampeloptin, Ampelopsin

Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.

Dihydromyricetin

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Purity: 98.22%

Catalog No. T2998Alias Ampeloptin, AmpelopsinCas No. 27200-12-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$139	In Stock	In Stock
500 mg	$346	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.22%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.
Targets&IC50	mTOR:48 μM
In vitro	Intraperitoneal injection of 1 mg/kg Dihydromyricetin in rats neutralizes the symptoms of acute alcohol intoxication and eliminates signs of increased tolerance, heightened anxiety, and susceptibility to convulsions. The LD50 for intraperitoneal injection in mice is 1.41 g/kg.
In vivo	Dihydromyricetin (1 μM), as an innovative anti-alcohol intoxication agent, antagonizes acute ethanol-induced enhancements in GABA(A)Rs, as well as increases in GABA(A)R plasticity and expression of the GABA(A)R α4 subunit in the hippocampus and cultured neurons due to ethanol exposure/withdrawal. Additionally, Dihydromyricetin effectively scavenges DPPH radicals and inhibits the increase in lipid peroxidation catalyzed by FeSO4 and ethylenediaminetetraacetic acid in the linoleic acid system.
Synonyms	Ampeloptin, Ampelopsin

Chemical Properties

Molecular Weight	320.25
Formula	C₁₅H₁₂O₈
Cas No.	27200-12-0
Smiles	O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1cc(O)c(O)c(O)c1
Relative Density.	1.808 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 60 mg/mL (187.35 mM), Sonication is recommended.

DMSO: 242 mg/mL (755.66 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1226 mL	15.6128 mL	31.2256 mL	156.1280 mL
5 mM	0.6245 mL	3.1226 mL	6.2451 mL	31.2256 mL
10 mM	0.3123 mL	1.5613 mL	3.1226 mL	15.6128 mL
20 mM	0.1561 mL	0.7806 mL	1.5613 mL	7.8064 mL
50 mM	0.0625 mL	0.3123 mL	0.6245 mL	3.1226 mL
100 mM	0.0312 mL	0.1561 mL	0.3123 mL	1.5613 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc