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Namodenoson

Name: Namodenoson
Brand: TargetMol
SKU: T6884
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6884Cas No. 163042-96-4

Alias CF-102, 2-Cl-IB-MECA

Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.

Namodenoson

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Purity: 98.97%

Catalog No. T6884Alias CF-102, 2-Cl-IB-MECACas No. 163042-96-4

Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$397	In Stock	In Stock
100 mg	$597	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.97%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.
Targets&IC50	A3 receptor:0.33 nM (Ki)
In vivo	The first infusion of Namodenoson resulted in a rapid fall of the blood pressure to a value which was about 50% of the pre-administration level.The hypotension was short-lasting.After approximately 15 min the blood pressure started to recover and rapidly returned to stable values, which were significantly lower than the blood pressure values in the control group.Administration of the second dose of Namodenoson, at 150 min after the first infusion, did not produce any hypotension at all.The slight increase in the mean arterial pressure during the second infusion was not specific for Namodenoson[1]
Animal Research	Rats were randomly assigned to two treatment groups of 6 animals, which received either two subsequent intravenous infusions of 200 μg/kg 2-chloro-N^6-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (2-Cl-IB-MECA) during 15 min or two subsequent infusions of the vehicle during 15 min. 2-Cl-IB-MECA was dissolved in dimethylsulfoxide (DMSO) and diluted with a sodium chloride solution to a final 30% (v/v) DMSO solution (a total volume of 765 μl).?Fresh solutions were prepared prior to each experiment.The effect measurements were started at least 45 min prior to the first drug infusion and lasted until 4.5 h after this infusion.?Heart rate and blood pressure were recorded continuously and serial arterial blood samples were drawn for determination of plasma histamine concentrations.?2 h after the first administration the second dose of 2-Cl-IB-MECA (or vehicle) was administered[1].
Synonyms	CF-102, 2-Cl-IB-MECA

Chemical Properties

Molecular Weight	544.73
Formula	C₁₈H₁₈ClIN₆O₄
Cas No.	163042-96-4
Smiles	CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12
Relative Density.	2.04 g/cm3 at 20℃

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31 mg/mL (56.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8358 mL	9.1789 mL	18.3577 mL	91.7886 mL
5 mM	0.3672 mL	1.8358 mL	3.6715 mL	18.3577 mL
10 mM	0.1836 mL	0.9179 mL	1.8358 mL	9.1789 mL
20 mM	0.0918 mL	0.4589 mL	0.9179 mL	4.5894 mL
50 mM	0.0367 mL	0.1836 mL	0.3672 mL	1.8358 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc