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AF38469

🥰Excellent
Catalog No. TQ0086Cas No. 1531634-31-7
Alias AF-38469

AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).

AF38469

AF38469

🥰Excellent
Purity: 99.18%
Catalog No. TQ0086Alias AF-38469Cas No. 1531634-31-7
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$89In StockIn Stock
2 mg$123In StockIn Stock
5 mg$189In StockIn Stock
10 mg$297In StockIn Stock
25 mg$579In StockIn Stock
50 mg$892In StockIn Stock
100 mg$1,220In StockIn Stock
200 mg$1,630-In Stock
1 mL x 10 mM (in DMSO)$198In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.18%
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Product Introduction

Bioactivity
Description
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
Targets&IC50
Sortilin:330 nM
In vitro
AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein.
SynonymsAF-38469
Chemical Properties
Molecular Weight324.25
FormulaC15H11F3N2O3
Cas No.1531634-31-7
SmilesCc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Relative Density.1.448 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (123.36 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (6.17 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0840 mL15.4202 mL30.8404 mL154.2020 mL
5 mM0.6168 mL3.0840 mL6.1681 mL30.8404 mL
10 mM0.3084 mL1.5420 mL3.0840 mL15.4202 mL
20 mM0.1542 mL0.7710 mL1.5420 mL7.7101 mL
50 mM0.0617 mL0.3084 mL0.6168 mL3.0840 mL
100 mM0.0308 mL0.1542 mL0.3084 mL1.5420 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SortilinNeurotensinReceptorNeurotensin ReceptorInhibitorinhibitAF38469AF 38469
Related Tags: buy AF38469 | purchase AF38469 | AF38469 cost | order AF38469 | AF38469 chemical structure | AF38469 in vitro | AF38469 formula | AF38469 molecular weight
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