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AF38469
🥰Excellent
Catalog No. TQ0086Cas No. 1531634-31-7
Alias AF-38469
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
AF38469
🥰Excellent
Purity: 99.18%
Catalog No. TQ0086Alias AF-38469Cas No. 1531634-31-7
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $94 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $319 | In Stock | |
| 25 mg | $595 | In Stock | |
| 50 mg | $896 | In Stock | |
| 100 mg | $1,220 | In Stock | |
| 200 mg | $1,630 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $219 | In Stock |
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Purity:99.18%
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Product Introduction
Bioactivity
Chemical Properties
| Description | AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM). |
| Targets&IC50 | Sortilin:330 nM |
| In vitro | AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein. |
| Synonyms | AF-38469 |
| Molecular Weight | 324.25 |
| Formula | C15H11F3N2O3 |
| Cas No. | 1531634-31-7 |
| Smiles | Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1 |
| Relative Density. | 1.448 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (123.36 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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