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AF38469

Name: AF38469
Brand: TargetMol
SKU: TQ0086
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0086Cas No. 1531634-31-7

Alias AF-38469

AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).

AF38469

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Purity: 99.18%

Catalog No. TQ0086Alias AF-38469Cas No. 1531634-31-7

AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
2 mg	$123	In Stock	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$579	In Stock	In Stock
50 mg	$892	In Stock	In Stock
100 mg	$1,220	In Stock	In Stock
200 mg	$1,630	-	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.18%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
Targets&IC50	Sortilin:330 nM
In vitro	AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein.
Synonyms	AF-38469

Chemical Properties

Molecular Weight	324.25
Formula	C₁₅H₁₁F₃N₂O₃
Cas No.	1531634-31-7
Smiles	Cc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1
Relative Density.	1.448 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (123.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (6.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0840 mL	15.4202 mL	30.8404 mL	154.2020 mL
5 mM	0.6168 mL	3.0840 mL	6.1681 mL	30.8404 mL
10 mM	0.3084 mL	1.5420 mL	3.0840 mL	15.4202 mL
20 mM	0.1542 mL	0.7710 mL	1.5420 mL	7.7101 mL
50 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0840 mL
100 mM	0.0308 mL	0.1542 mL	0.3084 mL	1.5420 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc