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Tetrahydrozoline

Name: Tetrahydrozoline
Brand: TargetMol
SKU: T0397
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0397Cas No. 84-22-0

Alias Tetryzoline, Tetryzolin

Tetrahydrozoline (Tetryzoline), an alpha agonist, have an effect on the constriction of conjunctival blood vessels. This contributes to relieve the redness of the eye resulted from minor ocular irritants.

Tetrahydrozoline

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Purity: 99.77%

Catalog No. T0397Alias Tetryzoline, TetryzolinCas No. 84-22-0

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	$48	In Stock	In Stock
500 mg	$129	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Tetrahydrozoline AI Summary

Tetrahydrozoline exhibits a range of bioactivities across different biological systems. It demonstrates central hypotensive activity with a 25% decrease in arterial pressure in anesthetized normotensive rats and induces hypertensive activity with a 60 mmHg increase in pithed rats. The compound has a partition coefficient (LogD) of -0.9 in octanol/buffer at pH 7.4 and shows binding affinities to alpha-1 and alpha-2 adrenergic receptors, with IC50 values of 1600.0 nM and 30.0 nM, respectively. It also interacts with the alpha-adrenergic receptors in the rabbit jejunum and rat brain. Moreover, Tetrahydrozoline has shown various receptor and enzyme activities, including: - Potentiation of the human D1 dopamine receptor at 2592.8 nM. - Inhibition of mammalian selenoprotein thioredoxin reductase 1 at 14125.4 nM. - Inhibition of regulator of G protein signaling 4 at 29.9 nM. - Enhancement of Arylsulfatase A at 756.9 nM. In antiviral research, it inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells with modest efficacy (IC50 > 19952.62 nM) and shows 17.25% inhibition against SARS-CoV-2 3CL-Pro protease at 20 µM. The compound also displayed varied inhibition rates against the human HDAC6 enzyme, suggesting inhibitory activity. The compound further displays binding affinities for human ADRA2A, HTR1A, OPRM1, and ADRA1A receptors, with notable agonist activity at human ADRA1A (AC50 of 6.1 nM). For other evaluated targets, significant activity was not observed (AC50 > 30000.0 nM). Tetrahydrozoline is noted for its absence of hepatic side effects according to the Drug Induced Liver Injury Prediction System (DILIps) training set, confirming a safe hepatic profile. Its basic pKa value is determined to be 10.6, indicating its behavior in biological environments. These diverse bioactivities highlight its significance for further pharmacological and antiviral studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tetrahydrozoline (Tetryzoline), an alpha agonist, have an effect on the constriction of conjunctival blood vessels. This contributes to relieve the redness of the eye resulted from minor ocular irritants.
Synonyms	Tetryzoline, Tetryzolin

Chemical Properties

Molecular Weight	200.28
Formula	C₁₃H₁₆N₂
Cas No.	84-22-0
Smiles	C1CN=C(N1)C1CCCc2ccccc12
Relative Density.	1.2 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (224.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9930 mL	24.9650 mL	49.9301 mL	249.6505 mL
5 mM	0.9986 mL	4.9930 mL	9.9860 mL	49.9301 mL
10 mM	0.4993 mL	2.4965 mL	4.9930 mL	24.9650 mL
20 mM	0.2497 mL	1.2483 mL	2.4965 mL	12.4825 mL
50 mM	0.0999 mL	0.4993 mL	0.9986 mL	4.9930 mL
100 mM	0.0499 mL	0.2497 mL	0.4993 mL	2.4965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc