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Triadimefon

Name: Triadimefon
Brand: TargetMol
SKU: T7726
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7726Cas No. 43121-43-3

Triadimefon is an azole fungicide used to control powdery mildew.

Triadimefon

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Purity: 99.66%

Catalog No. T7726Cas No. 43121-43-3

Triadimefon is an azole fungicide used to control powdery mildew.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$38	In Stock	In Stock
500 mg	$59	In Stock	In Stock
1 g	$71	In Stock	In Stock
5 g	$168	-	In Stock
10 g	$247	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.66%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Triadimefon AI Summary

Triadimefon exhibits a wide range of bioactivities including potent antifungal and antiviral properties. It displays significant antifungal activity against various pathogens such as Colletotrichum fragariae (zone of inhibition 121.0 mm), Helminthosporium sativum (MIC 20.0 µg/mL), Rhizoctonia solani (EC50 14.68 µg/mL), Botrytis cinerea, Gibberella zeae, Colletotrichum gossypii, and many others, with varying growth inhibition percentages from 35.0% to 95.0% at different concentrations. Furthermore, Triadimefon is a potent inhibitor of CYP3A4 with an IC50 value of 9289.66 nM and demonstrates binding affinity to Penicillium digitatum CYP51, with a Kd value of 935.5 nM. In plant protection, its antifungal efficacy has been noted against pathogens like Blumeria graminis f. sp. tritici, Venturia inaequalis, Bipolaris sorokiniana, and others, with considerable growth inhibition at concentrations as low as 50 ug/mL. Additionally, Triadimefon exhibits bioactivities in inhibiting SARS-CoV-2 3CL-Pro protease (22.22% inhibition at 20µM) and protecting VERO-6 cells from SARS-CoV-2-induced cytotoxicity, though requiring high concentrations (IC50 > 20,000 nM) for significant inhibition. Besides its antiviral and antifungal properties, it also influences various signaling pathways, such as being an activator and inhibitor in Cytochrome P450 3A4 activity, an agonist for estrogen receptor alpha, and an activator of the Aryl hydrocarbon receptor (AhR) signaling pathway..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Triadimefon is an azole fungicide used to control powdery mildew.

Chemical Properties

Molecular Weight	293.75
Formula	C₁₄H₁₆ClN₃O₂
Cas No.	43121-43-3
Smiles	CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1
Relative Density.	1.2200 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (153.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4043 mL	17.0213 mL	34.0426 mL	170.2128 mL
5 mM	0.6809 mL	3.4043 mL	6.8085 mL	34.0426 mL
10 mM	0.3404 mL	1.7021 mL	3.4043 mL	17.0213 mL
20 mM	0.1702 mL	0.8511 mL	1.7021 mL	8.5106 mL
50 mM	0.0681 mL	0.3404 mL	0.6809 mL	3.4043 mL
100 mM	0.0340 mL	0.1702 mL	0.3404 mL	1.7021 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc