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Metyrapone

Name: Metyrapone
Brand: TargetMol
SKU: T0293
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0293Cas No. 54-36-4

Alias Su-4885, NSC-25265

Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.

Metyrapone

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Purity: 99.52%

Catalog No. T0293Alias Su-4885, NSC-25265Cas No. 54-36-4

Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.

Pack Size	Price	Availability
50 mg	$34	In Stock
100 mg	$48	In Stock
500 mg	$147	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Purity:99.52%

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Product Introduction

Bioactivity

Description	Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
Targets&IC50	11β-HSD1:30 μM(Ki)
Synonyms	Su-4885, NSC-25265

Chemical Properties

Molecular Weight	226.27
Formula	C₁₄H₁₄N₂O
Cas No.	54-36-4
Smiles	CC(C)(C(=O)c1cccnc1)c1cccnc1
Relative Density.	1.0852 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.33 mg/mL (81.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4195 mL	22.0975 mL	44.1950 mL	220.9749 mL
5 mM	0.8839 mL	4.4195 mL	8.8390 mL	44.1950 mL
10 mM	0.4419 mL	2.2097 mL	4.4195 mL	22.0975 mL
20 mM	0.2210 mL	1.1049 mL	2.2097 mL	11.0487 mL
50 mM	0.0884 mL	0.4419 mL	0.8839 mL	4.4195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc