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Anti-B7-H3/CD276 Antibody (8H828)

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Catalog No. TMAB-02997

Anti-B7-H3/CD276 Antibody (8H828) is a Mouse antibody targeting B7-H3/CD276. Anti-B7-H3/CD276 Antibody (8H828) can be used in WB,IHC-P,IHC-Fr,IF.

Anti-B7-H3/CD276 Antibody (8H828)

Anti-B7-H3/CD276 Antibody (8H828)

😃Good
Catalog No. TMAB-02997
Anti-B7-H3/CD276 Antibody (8H828) is a Mouse antibody targeting B7-H3/CD276. Anti-B7-H3/CD276 Antibody (8H828) can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-B7-H3/CD276 Antibody (8H828) is a Mouse antibody targeting B7-H3/CD276. Anti-B7-H3/CD276 Antibody (8H828) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG1, k
Clone
8H828
Reactivity
Human
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-400; IHC-Fr: 1:100-400; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationMembrane; Single-pass type I membrane protein (Probable).
Tissue SpecificityUbiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Antigen Details
Immunogen
Recombinant Protein: human CD276
Antigen Species
Human
Gene Name
CD276
Gene ID
Protein Name
CD276 antigen
Uniprot ID
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Chemical Properties
Molecular WeightTheoretical: 54 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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