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5-Chloro-2'-deoxyuridine

Name: 5-Chloro-2'-deoxyuridine
Brand: TargetMol
SKU: T19151
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19151Cas No. 50-90-8

Alias CldU, 5-Chlorodeoxyuridine

5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.

5-Chloro-2'-deoxyuridine

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Purity: 99.54%

Catalog No. T19151Alias CldU, 5-ChlorodeoxyuridineCas No. 50-90-8

5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$40	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.54%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.
In vitro	The mammalian cells incorporate the analog into DNA when 5-Chloro-2’-deoxyuridine (ClDU) is placed into the tissue culture medium. It is observed that a 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In this study, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase [1].
Synonyms	CldU, 5-Chlorodeoxyuridine

Chemical Properties

Molecular Weight	262.65
Formula	C₉H₁₁ClN₂O₅
Cas No.	50-90-8
Smiles	OC[C@H]1O[C@H](C[C@@H]1O)n1cc(Cl)c(=O)[nH]c1=O
Relative Density.	1.67 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (475.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8073 mL	19.0367 mL	38.0735 mL	190.3674 mL
5 mM	0.7615 mL	3.8073 mL	7.6147 mL	38.0735 mL
10 mM	0.3807 mL	1.9037 mL	3.8073 mL	19.0367 mL
20 mM	0.1904 mL	0.9518 mL	1.9037 mL	9.5184 mL
50 mM	0.0761 mL	0.3807 mL	0.7615 mL	3.8073 mL
100 mM	0.0381 mL	0.1904 mL	0.3807 mL	1.9037 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc