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Chloramphenicol palmitate

Name: Chloramphenicol palmitate
Brand: TargetMol
SKU: T20525
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20525Cas No. 530-43-8

Chloramphenicol palmitate is a broad-spectrum antibiotic with activity against gram-positive and gram-negative bacteria. Chloramphenicol palmitate can be used in studies about acting as a bacterial selection agent in transformed cells containing chloramphenicol resistance genes.

Chloramphenicol palmitate

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Purity: 97%

Catalog No. T20525Cas No. 530-43-8

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$33	-	In Stock
1 g	$44	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Chloramphenicol palmitate AI Summary

Chloramphenicol palmitate exhibits an oral bioavailability of 80.0% in humans, indicating high absorption and potential effectiveness when taken orally. It demonstrates antiviral activity against SARS-CoV-2 by inhibiting the 3CL-Pro protease with an inhibition percentage of 19.34% at a concentration of 20μM. In cell-based assays, it shows activity by inhibiting the cytotoxic effects of the virus on Caco-2 cells with a 2.86% inhibition at 10μM after 48 hours, and a much lower 0.1% inhibition of cytotoxicity in VERO-6 cells under similar conditions. Additionally, in HRCE cells infected with the SARS-CoV-2 USA-WA1/2020 strain, Chloramphenicol palmitate demonstrated limited efficacy with a low hit score of 0.136 at MOI 0.4 after 96 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	561.54
Formula	C₂₇H₄₂Cl₂N₂O₆
Cas No.	530-43-8
Smiles	CCCCCCCCCCCCCCCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
Relative Density.	1.172 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (169.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7808 mL	8.9041 mL	17.8082 mL	89.0409 mL
5 mM	0.3562 mL	1.7808 mL	3.5616 mL	17.8082 mL
10 mM	0.1781 mL	0.8904 mL	1.7808 mL	8.9041 mL
20 mM	0.0890 mL	0.4452 mL	0.8904 mL	4.4520 mL
50 mM	0.0356 mL	0.1781 mL	0.3562 mL	1.7808 mL
100 mM	0.0178 mL	0.0890 mL	0.1781 mL	0.8904 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc