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Cyclo(Ile-Ala)

Name: Cyclo(Ile-Ala)
Brand: TargetMol
SKU: TMA1403
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMA1403Cas No. 90821-99-1

Helicin is a syrB inducer found in the Rosaceae family. Helicin is hydrolyzed by the enzyme BglY.

Cyclo(Ile-Ala)

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Purity: 99.76%

Catalog No. TMA1403Cas No. 90821-99-1

Helicin is a syrB inducer found in the Rosaceae family. Helicin is hydrolyzed by the enzyme BglY.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$166	In Stock	In Stock
100 mg	$245	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Helicin is a syrB inducer found in the Rosaceae family. Helicin is hydrolyzed by the enzyme BglY.

In vitro

To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.METHODS AND RESULTS: Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),Cyclo(Ile-Ala) (2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),cyclo(Ala-Pro)(5) and cyclo(Phe-Val)(6).CONCLUSIONS: Compounds 1-6 are reported as new cell cycle inhibitors for the first time.

Chemical Properties

Molecular Weight	184.24
Formula	C₉H₁₆N₂O₂
Cas No.	90821-99-1
Smiles	CCC(C)C1NC(=O)C(C)NC1=O
Relative Density.	1.022 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.6 mg/mL (30.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4277 mL	27.1385 mL	54.2770 mL	271.3851 mL
5 mM	1.0855 mL	5.4277 mL	10.8554 mL	54.2770 mL
10 mM	0.5428 mL	2.7139 mL	5.4277 mL	27.1385 mL
20 mM	0.2714 mL	1.3569 mL	2.7139 mL	13.5693 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc