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NCGC 607

Name: NCGC 607
Brand: TargetMol
SKU: T8989
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8989Cas No. 1462267-07-7

Alias NCGC607

NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).

NCGC 607

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Purity: 99.69%

Catalog No. T8989Alias NCGC607Cas No. 1462267-07-7

NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$41	In Stock	In Stock
5 mg	$83	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$225	In Stock	In Stock
50 mg	$332	-	In Stock
100 mg	$473	-	In Stock
200 mg	$663	-	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).
In vitro	NCGC607, a small-molecule noninhibitory chaperone of glucocerebrosidase identified by high-throughput screening and medicinal chemistry structure optimization.?This compound successfully chaperoned the mutant enzyme, restored glucocerebrosidase activity and protein levels, and reduced glycolipid storage in both iPSC-derived macrophages and dopaminergic neurons, indicating its potential for treating neuronopathic Gaucher disease.?In addition, NCGC607 reduced α-synuclein levels in dopaminergic neurons from the patients with parkinsonism, suggesting that noninhibitory small-molecule chaperones of glucocerebrosidase may prove useful for the treatment of Parkinson disease.
Synonyms	NCGC607

Chemical Properties

Molecular Weight	543.35
Formula	C₂₄H₂₂IN₃O₄
Cas No.	1462267-07-7
Smiles	CN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(I)cc1)c1ccccc1
Relative Density.	1.555 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (101.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8404 mL	9.2022 mL	18.4043 mL	92.0217 mL
5 mM	0.3681 mL	1.8404 mL	3.6809 mL	18.4043 mL
10 mM	0.1840 mL	0.9202 mL	1.8404 mL	9.2022 mL
20 mM	0.0920 mL	0.4601 mL	0.9202 mL	4.6011 mL
50 mM	0.0368 mL	0.1840 mL	0.3681 mL	1.8404 mL
100 mM	0.0184 mL	0.0920 mL	0.1840 mL	0.9202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc