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Anti-KIRREL3 Polyclonal Antibody

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Catalog No. TMAB-08079

Anti-KIRREL3 Polyclonal Antibody is a Rabbit antibody targeting KIRREL3. Anti-KIRREL3 Polyclonal Antibody can be used in FCM.

Anti-KIRREL3 Polyclonal Antibody

Anti-KIRREL3 Polyclonal Antibody

😃Good
Catalog No. TMAB-08079
Anti-KIRREL3 Polyclonal Antibody is a Rabbit antibody targeting KIRREL3. Anti-KIRREL3 Polyclonal Antibody can be used in FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-KIRREL3 Polyclonal Antibody is a Rabbit antibody targeting KIRREL3. Anti-KIRREL3 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Chicken)
Application
FCM
Recommended Dose
FCM: 1μg/Test
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane; Single-pass type I membrane protein
Tissue SpecificityExpressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundNEPH2 is a 778 amino acid single-pass type I membrane protein that belongs to the nephrin-like protein family and immunoglobulin superfamily. Expressed in both fetal and adult brain, as well as podocytes of kidney glomeruli, NEPH2 contains five Ig-like C2-type (immunoglobulin-like) domains and is thought to plaly a role in the hematopoetic supportive capacity of stroma cells. NEPH2 undergoes alternative splicing to produce two isoforms and contains a C-terminal cytoplasmic domain which it uses to interact with Podocin, a podocyte protein involved in ultrafiltration. Defects in the gene encoding NEPH2 are associated with mental retardation autosomal dominant type 4 (MRD4).
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human KIRREL3
Antigen Species
Human
Gene Name
KIRREL3
Gene ID
84623
Protein Name
Kin of IRRE-like protein 3
Uniprot ID
Q8IZU9
Function
NEPH2 is a member of the nephrin like protein family, which includes NEPH1 (KIRREL; MIM 607428) and NEPH3 (KIRREL2; MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size and charge selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).
Chemical Properties
Molecular WeightTheoretical: 83 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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