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Anti-KIRREL3 Polyclonal Antibody
Catalog No. TMAB-08079 Copy Product Info
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Anti-KIRREL3 Polyclonal Antibody is a Rabbit antibody targeting KIRREL3. Anti-KIRREL3 Polyclonal Antibody can be used in FCM.
Anti-KIRREL3 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-08079
Anti-KIRREL3 Polyclonal Antibody is a Rabbit antibody targeting KIRREL3. Anti-KIRREL3 Polyclonal Antibody can be used in FCM.
Anti-KIRREL3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-KIRREL3 Polyclonal Antibody is a Rabbit antibody targeting KIRREL3. Anti-KIRREL3 Polyclonal Antibody can be used in FCM. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken) |
| Verified Activity | Blank control (blue): Mouse nephrocytes (fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-KIRREL3 antibody (TMAB-08079), Dilution: 1 μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG (orange), used under the same conditions); Secondary Antibody: Goat anti-rabbit IgG-PE (white blue), Dilution: 1: 200 in 1 X PBS containing 0.5% BSA. |
| Application | |
| Recommended Dose | FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein |
| Tissue Specificity | Expressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | NEPH2 is a 778 amino acid single-pass type I membrane protein that belongs to the nephrin-like protein family and immunoglobulin superfamily. Expressed in both fetal and adult brain, as well as podocytes of kidney glomeruli, NEPH2 contains five Ig-like C2-type (immunoglobulin-like) domains and is thought to plaly a role in the hematopoetic supportive capacity of stroma cells. NEPH2 undergoes alternative splicing to produce two isoforms and contains a C-terminal cytoplasmic domain which it uses to interact with Podocin, a podocyte protein involved in ultrafiltration. Defects in the gene encoding NEPH2 are associated with mental retardation autosomal dominant type 4 (MRD4). |
| Immunogen | KLH conjugated synthetic peptide: human KIRREL3 |
| Antigen Species | Human |
| Gene Name | KIRREL3 |
| Gene ID | |
| Protein Name | Kin of IRRE-like protein 3 |
| Uniprot ID | |
| Function | NEPH2 is a member of the nephrin like protein family, which includes NEPH1 (KIRREL; MIM 607428) and NEPH3 (KIRREL2; MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size and charge selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]). |
| Molecular Weight | Theoretical: 83 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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