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Almitrine mesylate

Name: Almitrine mesylate
Brand: TargetMol
SKU: T6978
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6978Cas No. 29608-49-9

Alias Almitrine dimesylate, Almitrine bismethanesulfonate, Almitrine bismesylate

Almitrine mesylate (Almitrine dimesylate) inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cells,used in the treatment of hypoxemic chronic lung diseases.

Almitrine mesylate

🥰Excellent

Purity: 99.96%

Catalog No. T6978Alias Almitrine dimesylate, Almitrine bismethanesulfonate, Almitrine bismesylateCas No. 29608-49-9

Almitrine mesylate (Almitrine dimesylate) inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cells,used in the treatment of hypoxemic chronic lung diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	-
50 mg	$46	In Stock	-
100 mg	$78	In Stock	-
200 mg	$108	In Stock	-
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.96%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Almitrine mesylate (Almitrine dimesylate) inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cells,used in the treatment of hypoxemic chronic lung diseases.
In vivo	Almitrine dimesylate is a drug used in the treatment of hypoxemic chronic lung diseases such as bronchitis and emphysema because it is a potent stimulant of the carotid bodies in human and different animal species that produces a long-lasting enhancement of alveolar ventilation, ameliorating arterial blood gases[1].
Synonyms	Almitrine dimesylate, Almitrine bismethanesulfonate, Almitrine bismesylate

Chemical Properties

Molecular Weight	669.76
Formula	C₂₈H₃₇F₂N₇O₆S₂
Cas No.	29608-49-9
Smiles	CS(O)(=O)=O.CS(O)(=O)=O.Fc1ccc(cc1)C(N1CCN(CC1)c1nc(NCC=C)nc(NCC=C)n1)c1ccc(F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (186.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (5.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4931 mL	7.4654 mL	14.9307 mL	74.6536 mL
5 mM	0.2986 mL	1.4931 mL	2.9861 mL	14.9307 mL
10 mM	0.1493 mL	0.7465 mL	1.4931 mL	7.4654 mL
20 mM	0.0747 mL	0.3733 mL	0.7465 mL	3.7327 mL
50 mM	0.0299 mL	0.1493 mL	0.2986 mL	1.4931 mL
100 mM	0.0149 mL	0.0747 mL	0.1493 mL	0.7465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc