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Targocil
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Synonyms:
Catalog No. T4208 Copy Product Info
Purity: 99.12%
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Targocil is used as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) (MIC90s: 2 μg/ mL) for both MRSA and MSSA.
Cas No. 1200443-21-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 2 mg | $35 | In Stock | In Stock | |
| 5 mg | $59 | In Stock | In Stock | |
| 10 mg | $94 | In Stock | In Stock | |
| 25 mg | $176 | In Stock | In Stock | |
| 50 mg | $286 | In Stock | In Stock | |
| 100 mg | $401 | In Stock | In Stock | |
| 200 mg | $562 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.12%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Targocil is used as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) (MIC90s: 2 μg/ mL) for both MRSA and MSSA. |
| Targets & IC50 | MSSA:2 μg/mL (MIC90), MRSA:2 μg/mL (MIC90) |
| In vitro | Targocil can inhibit the growth of S. aureus strains Newman, MG2375, MW2, and MG2389 (MICs: 1 μg/mL). Targocil has obviously activity against S. aureus isolates from suspected cases of bacterial keratitis, including both MSSA and MRSA isolates (MICs: 1-2 μg/ mL). Compare to the vehicle alone, Targocil (5 μg/mL) exhibits little toxicity for HCECs, even after 24 h of exposure. However, 40 μg/mL Targocil shows toxicity at all time points tested. In the presence of HCECs, Targocil at levels equal to 10×MIC in vitro readily inhibits the growth of MG2375 and Newman. |
| Molecular Weight | 475.95 |
| Formula | C21H22ClN5O4S |
| Cas No. | 1200443-21-5 |
| Smiles | CCN(CC)c1nc2c(nnn2c2cc(OC)c(OC)cc12)S(=O)(=O)c1ccc(Cl)cc1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 3.68 mg/mL (7.73 mM), Sonication is recommended.  | |||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Saline: 0.37 mg/mL (0.78 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Targocil chemical structure | Targocil in vitro | Targocil formula | Targocil molecular weight
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