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Niacin
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Catalog No. T0879Cas No. 59-67-6
Alias Vitamin B3, Nicotinic acid
Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.
Niacin
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Purity: 99.96%
Catalog No. T0879Alias Vitamin B3, Nicotinic acidCas No. 59-67-6
Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $37 | In Stock | In Stock | |
| 1 g | $50 | In Stock | In Stock | |
| 5 g | $73 | - | In Stock | |
| 10 g | $106 | Inquiry | Inquiry | |
| 25 g | $176 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.96%
Appearance:Solid
Color:White
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Product Introduction
Niacin AI Summary
Niacin shows a range of bioactivities across various biological systems. It effectively reduces plasma triglycerides and total cholesterol levels in both cholesterol-fed and normocholesterolemic rats, also increasing HDL cholesterol levels. The compound demonstrates significant hypolipidemic effects, affecting serum cholesterol, HDL, and LDL levels. At specific doses, it lowers serum triglyceride levels and decreases liver weight in rats.
Additionally, Niacin exhibits agonist activity at the GPR109A receptor, inhibiting forskolin-induced cAMP generation with potent EC50 values, and displacing niacin in binding assays, showing strong receptor interaction. Its therapeutic effects include the reduction of free fatty acid levels and vasodilation in animal models. The compound also has good oral bioavailability and fast plasma clearance in mice.
The compound demonstrates significant inhibitory activity against several enzymes and has been observed to inhibit amyloid beta aggregation and sodium fluorescein uptake, indicating potential applications in neurological and hepatic conditions. It also shows moderate liver toxicity potential based on clinical trial frequency.
As an antifungal and antimicrobial agent, Niacin exhibits activity against various pathogens, including ordinary and drug-resistant strains of bacteria and fungi. It also displays nematotoxic and antiviral activities against certain viruses, including moderate effects on SARS-CoV-2 cytotoxicity.
Overall, Niacin appears to have diverse bioactivities with potential therapeutic applications in dyslipidemia, cardiovascular health, antimicrobial resistance, liver conditions, and specific viral infections, while also noting some concerns regarding liver toxicity..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. |
| Synonyms | Vitamin B3, Nicotinic acid |
| Molecular Weight | 123.11 |
| Formula | C6H5NO2 |
| Cas No. | 59-67-6 |
| Smiles | OC(=O)C1=CC=CN=C1 |
| Relative Density. | 1.473 g/cm3. Temperature:25 °C. |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 2 mg/mL (16.25 mM), Sonication is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (406.14 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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