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Methylproamine

🥰Excellent
Catalog No. T12019Cas No. 188247-01-0

Methylproamine is a DNA-binding radioprotector that acts by repairing transient radiation-induced oxidative species on DNA.

Methylproamine

Methylproamine

🥰Excellent
Purity: 99.94%
Catalog No. T12019Cas No. 188247-01-0
Methylproamine is a DNA-binding radioprotector that acts by repairing transient radiation-induced oxidative species on DNA.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$30In StockIn Stock
10 mg$44In StockIn Stock
25 mg$68In StockIn Stock
50 mg$98In StockIn Stock
100 mg$165In StockIn Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.94%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Methylproamine is a DNA-binding radioprotector that acts by repairing transient radiation-induced oxidative species on DNA.
In vitro
Immunocytochemical methods were used to measure the accumulation of phosphorylated H2AX (γH2AX) foci following ionizing radiation (IR) in patient-derived lymphoblastoid cells exposed to methylproamine. Pulsed field gel electrophoresis DNA damage and repair assays were performed to directly interrogate the action of methylproamine on DNA in irradiated cells.Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence of methylproamine decreased the amount of lower molecular weight DNA entering the gel[2].
Chemical Properties
Molecular Weight465.59
FormulaC28H31N7
Cas No.188247-01-0
SmilesCN(C)C1=CC(C)=C(C=C1)C1=NC2=CC=C(C=C2N1)C1=NC2=CC=C(C=C2N1)N1CCN(C)CC1
Relative Density.1.262 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 55 mg/mL (118.13 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.15 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1478 mL10.7391 mL21.4781 mL107.3906 mL
5 mM0.4296 mL2.1478 mL4.2956 mL21.4781 mL
10 mM0.2148 mL1.0739 mL2.1478 mL10.7391 mL
20 mM0.1074 mL0.5370 mL1.0739 mL5.3695 mL
50 mM0.0430 mL0.2148 mL0.4296 mL2.1478 mL
100 mM0.0215 mL0.1074 mL0.2148 mL1.0739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RadioprotectorMethylproamineInhibitorinhibitDNA/RNA SynthesisDNA double-strand
Related Tags: buy Methylproamine | purchase Methylproamine | Methylproamine cost | order Methylproamine | Methylproamine chemical structure | Methylproamine in vitro | Methylproamine formula | Methylproamine molecular weight
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