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BMS-833923

Name: BMS-833923
Brand: TargetMol
SKU: T2299
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2299Cas No. 1059734-66-5

Alias XL-139

BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).

BMS-833923

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Purity: 99.76%

Catalog No. T2299Alias XL-139Cas No. 1059734-66-5

BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$46	In Stock	In Stock
10 mg	$74	In Stock	In Stock
25 mg	$129	In Stock	In Stock
50 mg	$208	In Stock	In Stock
100 mg	$376	In Stock	In Stock
200 mg	$553	-	In Stock
500 mg	$878	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

BMS-833923 AI Summary

BMS-833923 exhibits antiviral activity against SARS-CoV-2, demonstrated by its ability to inhibit virus-induced cytotoxicity in Caco-2 cells with a 68.77% inhibition rate at 10 µM after 48 hours and in VERO-E6 cells as well. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease with a percentage inhibition of -29.73% at 20 µM using a FRET-based assay. The compound's variability in IC50 values indicates its potency in reducing viral-induced cell damage, and toxicity against VERO-E6 cells was assessed with a CC50 value reported. Besides its antiviral properties, BMS-833923 also shows inhibitory activity towards human HDAC6 with inhibition percentages of -7.66% and -3.15% using different peptide substrates. Furthermore, it demonstrates antischistosomal activity against Schistosoma mansoni with IC50 values of 3500.0 nM and 2500.0 nM, as assessed by microscopic methods after 72 hours, although it failed to reduce worm burden in NMRI mice when administered at 200 mg/kg orally..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Targets&IC50	BODIPY:21 nM
In vivo	BMS-833923 dose-dependently affected the transcription of prostate hedgehog signaling genes in vitro.BMS-833923 caused a decrease in hedgehog pathway activity, reduced cell proliferation, and induced apoptosis in esophageal adenocarcinoma cell lines via an endogenous pathway.
Synonyms	XL-139

Chemical Properties

Molecular Weight	473.57
Formula	C₃₀H₂₇N₅O
Cas No.	1059734-66-5
Smiles	CNCc1ccc(C)c(NC(=O)c2ccc(Nc3nc(-c4ccccc4)c4ccccc4n3)cc2)c1
Relative Density.	1.252 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 88 mg/mL (185.82 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1116 mL	10.5581 mL	21.1162 mL	105.5810 mL
5 mM	0.4223 mL	2.1116 mL	4.2232 mL	21.1162 mL
10 mM	0.2112 mL	1.0558 mL	2.1116 mL	10.5581 mL
20 mM	0.1056 mL	0.5279 mL	1.0558 mL	5.2791 mL
50 mM	0.0422 mL	0.2112 mL	0.4223 mL	2.1116 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc