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BMS-833923

Name: BMS-833923
Brand: TargetMol
SKU: T2299
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2299Cas No. 1059734-66-5

Alias XL-139

BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).

BMS-833923

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Purity: 99.76%

Catalog No. T2299Alias XL-139Cas No. 1059734-66-5

BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).

Pack Size	Price	Availability
5 mg	$46	In Stock
10 mg	$74	In Stock
25 mg	$129	In Stock
50 mg	$208	In Stock
100 mg	$376	In Stock
200 mg	$553	In Stock
500 mg	$878	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Purity:99.76%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Targets&IC50	BODIPY:21 nM
In vivo	BMS-833923 dose-dependently affected the transcription of prostate hedgehog signaling genes in vitro.BMS-833923 caused a decrease in hedgehog pathway activity, reduced cell proliferation, and induced apoptosis in esophageal adenocarcinoma cell lines via an endogenous pathway.
Synonyms	XL-139

Chemical Properties

Molecular Weight	473.57
Formula	C₃₀H₂₇N₅O
Cas No.	1059734-66-5
Smiles	CNCc1ccc(C)c(NC(=O)c2ccc(Nc3nc(-c4ccccc4)c4ccccc4n3)cc2)c1
Relative Density.	1.252 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 88 mg/mL (185.82 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1116 mL	10.5581 mL	21.1162 mL	105.5810 mL
5 mM	0.4223 mL	2.1116 mL	4.2232 mL	21.1162 mL
10 mM	0.2112 mL	1.0558 mL	2.1116 mL	10.5581 mL
20 mM	0.1056 mL	0.5279 mL	1.0558 mL	5.2791 mL
50 mM	0.0422 mL	0.2112 mL	0.4223 mL	2.1116 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc