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Nafamostat

Name: Nafamostat
Brand: TargetMol
SKU: T23052
Rating: 4.5 (1 reviews)

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Catalog No. T23052Cas No. 81525-10-2

Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.

Nafamostat

😃Good

Catalog No. T23052Cas No. 81525-10-2

Pack Size	Price	Availability	Quantity
1 mg	$85	7-10 days

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Product Introduction

Bioactivity

Description	Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.
In vitro	Nafamostat (10-80 μg/mL, 3-48 h) treatment of MDAPanc-28 cells can inhibit NF-κB activity by blocking IκBα phosphorylation, and when the concentration reaches 80 μg/mL and the treatment time is 24-48 h, it can induce apoptosis of MDAPanc-28 cells by upregulating the expression of tumor necrosis factor receptor 1 (TNFR1). [1]
In vivo	Nafamostat (10 mg/kg, intraperitoneal injection, once a day, 18 days) was used to treat A129 mice infected with Zika virus (ZIKV), and it was found that Nafamostat has a good antiviral effect in vivo. [3]

Chemical Properties

Molecular Weight	347.37
Formula	C₁₉H₁₇N₅O₂
Cas No.	81525-10-2
Smiles	O=C(OC=1C=CC2=CC(=CC=C2C1)C(=N)N)C3=CC=C(C=C3)NC(=N)N
Relative Density.	1.39g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (11.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8788 mL	14.3939 mL	28.7877 mL	143.9387 mL
5 mM	0.5758 mL	2.8788 mL	5.7575 mL	28.7877 mL
10 mM	0.2879 mL	1.4394 mL	2.8788 mL	14.3939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc