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Nafamostat

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Catalog No. T23052Cas No. 81525-10-2

Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.

Nafamostat

Nafamostat

😃Good
Catalog No. T23052Cas No. 81525-10-2
Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.
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1 mg$857-10 days
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Product Introduction

Bioactivity
Description
Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.
In vitro
Nafamostat (10-80 μg/mL, 3-48 h) treatment of MDAPanc-28 cells can inhibit NF-κB activity by blocking IκBα phosphorylation, and when the concentration reaches 80 μg/mL and the treatment time is 24-48 h, it can induce apoptosis of MDAPanc-28 cells by upregulating the expression of tumor necrosis factor receptor 1 (TNFR1). [1]
In vivo
Nafamostat (10 mg/kg, intraperitoneal injection, once a day, 18 days) was used to treat A129 mice infected with Zika virus (ZIKV), and it was found that Nafamostat has a good antiviral effect in vivo. [3]
Chemical Properties
Molecular Weight347.37
FormulaC19H17N5O2
Cas No.81525-10-2
SmilesO=C(OC=1C=CC2=CC(=CC=C2C1)C(=N)N)C3=CC=C(C=C3)NC(=N)N
Relative Density.1.39g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4 mg/mL (11.52 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8788 mL14.3939 mL28.7877 mL143.9387 mL
5 mM0.5758 mL2.8788 mL5.7575 mL28.7877 mL
10 mM0.2879 mL1.4394 mL2.8788 mL14.3939 mL

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