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Nafamostat

Name: Nafamostat
Brand: TargetMol
SKU: T23052
Rating: 4.5 (1 reviews)

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Catalog No. T23052Cas No. 81525-10-2

Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.

Nafamostat

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Catalog No. T23052Cas No. 81525-10-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$85	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.
In vitro	Nafamostat (10-80 μg/mL, 3-48 h) treatment of MDAPanc-28 cells can inhibit NF-κB activity by blocking IκBα phosphorylation, and when the concentration reaches 80 μg/mL and the treatment time is 24-48 h, it can induce apoptosis of MDAPanc-28 cells by upregulating the expression of tumor necrosis factor receptor 1 (TNFR1). [1]
In vivo	Nafamostat (10 mg/kg, intraperitoneal injection, once a day, 18 days) was used to treat A129 mice infected with Zika virus (ZIKV), and it was found that Nafamostat has a good antiviral effect in vivo. [3]

Chemical Properties

Molecular Weight	347.37
Formula	C₁₉H₁₇N₅O₂
Cas No.	81525-10-2
Smiles	O=C(OC=1C=CC2=CC(=CC=C2C1)C(=N)N)C3=CC=C(C=C3)NC(=N)N
Relative Density.	1.39g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (11.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8788 mL	14.3939 mL	28.7877 mL	143.9387 mL
5 mM	0.5758 mL	2.8788 mL	5.7575 mL	28.7877 mL
10 mM	0.2879 mL	1.4394 mL	2.8788 mL	14.3939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc