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7-Epi 10-desacetyl paclitaxel

Name: 7-Epi 10-desacetyl paclitaxel
Brand: TargetMol
SKU: T5738
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5738Cas No. 78454-17-8

Alias 7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxel

7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.

7-Epi 10-desacetyl paclitaxel

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Purity: 99.01%

Catalog No. T5738Alias 7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxelCas No. 78454-17-8

7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$219	In Stock	In Stock
100 mg	$326	In Stock	In Stock
200 mg	$485	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.01%

Color:White

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Product Introduction

Bioactivity

Description	7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
In vitro	7-Epi-10-deacetyltaxol(EDT) exhibited significant in vitro cytotoxicity in HepG2 cells.Nuclear condensation and DNA fragmentation were observed in cells treated with fungal EDT.?Besides, the fungal EDT arrested HepG2 cells at G2/M phase of cell cycle.?Furthermore, fungal EDT induced apoptosis in HepG2 cells in a dose-dependent manner associated with ROS generation and increased Bax/Bcl-2 ratio, p38 MAPKs and PARP cleavage[1].
Cell Research	The endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal 7-Epi-10-deacetyltaxol(EDT) was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel.?Studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology.?Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression[1].
Synonyms	7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxel

Chemical Properties

Molecular Weight	811.87
Formula	C₄₅H₄₉NO₁₃
Cas No.	78454-17-8
Smiles	[H][C@@]12C[C@@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (123.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2317 mL	6.1586 mL	12.3172 mL	61.5862 mL
5 mM	0.2463 mL	1.2317 mL	2.4634 mL	12.3172 mL
10 mM	0.1232 mL	0.6159 mL	1.2317 mL	6.1586 mL
20 mM	0.0616 mL	0.3079 mL	0.6159 mL	3.0793 mL
50 mM	0.0246 mL	0.1232 mL	0.2463 mL	1.2317 mL
100 mM	0.0123 mL	0.0616 mL	0.1232 mL	0.6159 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc