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Nalidixic acid sodium salt

Name: Nalidixic acid sodium salt
Brand: TargetMol
SKU: T0909L
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0909LCas No. 3374-05-8

Alias Sodium nalidixate, Baktogram

Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.

Nalidixic acid sodium salt

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Purity: 99.95%

Catalog No. T0909LAlias Sodium nalidixate, BaktogramCas No. 3374-05-8

Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$31	In Stock	In Stock
200 mg	$47	In Stock	In Stock
500 mg	$83	In Stock	In Stock
1 g	$122	-	In Stock
2 g	$178	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Nalidixic acid sodium salt AI Summary

Nalidixic acid sodium salt exhibits a broad spectrum of bioactivities. It is a potent agonist of the NFkB signaling pathway with a potency of 3.5 nM. The compound also functions as an inhibitor in various assays, showing efficacy against Influenza NS1 protein function, JMJD2E, HADH2, BAZ2B, and Bloom's syndrome helicase (BLM), with inhibition potencies ranging from 7.1 nM to 31622.8 nM. Additionally, it acts both as an inhibitor and an antagonist of the NFkB signaling pathway, exhibiting potencies of 3.5 nM and 79432.8 nM, respectively. In a Cytochrome panel assay, it has an AC50 value of 31622.78 nM. The compound has also been tested as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1), with a potency of 35481.3 nM. However, it does not inhibit cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at MOI 0.002 after 72 hours, indicated by a negative inhibition index of -0.007949..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.
Synonyms	Sodium nalidixate, Baktogram

Chemical Properties

Molecular Weight	254.22
Formula	C₁₂H₁₁N₂NaO₃
Cas No.	3374-05-8
Smiles	[Na+].CCn1cc(C([O-])=O)c(=O)c2ccc(C)nc12
Relative Density.	1.331g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Slightly soluble

H2O: 125 mg/mL (491.7 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.9336 mL	19.6680 mL	39.3360 mL	196.6800 mL
5 mM	0.7867 mL	3.9336 mL	7.8672 mL	39.3360 mL
10 mM	0.3934 mL	1.9668 mL	3.9336 mL	19.6680 mL
20 mM	0.1967 mL	0.9834 mL	1.9668 mL	9.8340 mL
50 mM	0.0787 mL	0.3934 mL	0.7867 mL	3.9336 mL
100 mM	0.0393 mL	0.1967 mL	0.3934 mL	1.9668 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc