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N-Methylisatoic anhydride

Name: N-Methylisatoic anhydride
Brand: TargetMol
SKU: T16239
Rating: 4.5 (1 reviews)

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Catalog No. T16239Cas No. 10328-92-4

Alias NMIA

N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs. It is also widely used for resolving secondary RNA structures using the SHAPE technology.

N-Methylisatoic anhydride

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Catalog No. T16239Alias NMIACas No. 10328-92-4

N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs. It is also widely used for resolving secondary RNA structures using the SHAPE technology.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	Inquiry	Inquiry
500 mg	$53	Inquiry	Inquiry
1 g	$77	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

N-Methylisatoic anhydride AI Summary

N-Methylisatoic anhydride is a multifunctional bioactive molecule with notable inhibitory and agonistic properties. It is a potent inhibitor of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) with a potency of 56234.1 nM and also exhibits inhibitory activity against the Marburg Virus by impeding its binding or entry into cells with a potency of 5623.4 nM. Furthermore, it acts as a substrate for TrxR1 with a potency of 25118.9 nM and inhibits Secretory Acid Sphingomyelinase (S-ASM) with a potency of 31622.8 nM. Additionally, N-Methylisatoic anhydride functions as an agonist for the gsp mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome, with a potency of 11220.2 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs. It is also widely used for resolving secondary RNA structures using the SHAPE technology.
Synonyms	NMIA

Chemical Properties

Molecular Weight	177.16
Formula	C₉H₇NO₃
Cas No.	10328-92-4
Smiles	CN1C(=O)OC(=O)C2=CC=CC=C12
Relative Density.	1.3312 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (338.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6446 mL	28.2231 mL	56.4462 mL	282.2308 mL
5 mM	1.1289 mL	5.6446 mL	11.2892 mL	56.4462 mL
10 mM	0.5645 mL	2.8223 mL	5.6446 mL	28.2231 mL
20 mM	0.2822 mL	1.4112 mL	2.8223 mL	14.1115 mL
50 mM	0.1129 mL	0.5645 mL	1.1289 mL	5.6446 mL
100 mM	0.0564 mL	0.2822 mL	0.5645 mL	2.8223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc