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Propylparaben

Name: Propylparaben
Brand: TargetMol
SKU: T5557
Rating: 4.5 (1 reviews)

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Catalog No. T5557Cas No. 94-13-3

Alias Propyl parahydroxybenzoate, Propyl 4-hydroxybenzoate

Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial agent, preservative, and flavoring agent.

Propylparaben

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Purity: 99.84%

Catalog No. T5557Alias Propyl parahydroxybenzoate, Propyl 4-hydroxybenzoateCas No. 94-13-3

Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial agent, preservative, and flavoring agent.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial agent, preservative, and flavoring agent.
In vitro	Propylparaben(PPB) suppressed the epileptiform activity in registered neurons.?This effect disappeared when PPB was removed from the solution of incubation.?PPB exerts an antiepileptic effect on CA1 pyramidal neurons in vitro.?Therefore, PPB may represent an effective antiepileptic compound[1]. propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways[1].
Cell Research	Experimental conditions were as follows: a) basal recordings during which artificial cerebrospinal fluid (ACSF) (in mM: NaCl,125; KCl, 3; Na2HPO4, 1.25; NaHCO3, 25; MgCl2, 2; CaCl2, 2-D-(+)-glucose, 10; gassed with a mixture of 95% O2–5% CO2) was perfused; b) ACSF plus Propylparaben(PPB) (500 μM); c) 4-AP (100 μM) in Mg2+free-ACSF; d) 4-AP in Mg2+free-ACSF plus vehicle (dimethyl sulfoxide, DMSO at 0.04%); e) 4-AP in Mg2+free-ACSF plus drugs (phenytoin (PHT), 200 μM; PPB, 200 and 7500 μM). Each experimental condition lasted for 10 min. The onset of 4-AP-induced epileptiform activity was considered when bursts of 5 of more consecutive action potentials (APs) were present. The number of APs and excitatory postsynaptic potentials (EPSPs) greater than 1 mV and less than 10 mV of amplitude were quantified during periods of 5 min for each experimental condition[2]
Synonyms	Propyl parahydroxybenzoate, Propyl 4-hydroxybenzoate

Chemical Properties

Molecular Weight	180.20
Formula	C₁₀H₁₂O₃
Cas No.	94-13-3
Smiles	C(OCCC)(=O)C1=CC=C(O)C=C1
Relative Density.	1.287 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (332.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5494 mL	27.7469 mL	55.4939 mL	277.4695 mL
5 mM	1.1099 mL	5.5494 mL	11.0988 mL	55.4939 mL
10 mM	0.5549 mL	2.7747 mL	5.5494 mL	27.7469 mL
20 mM	0.2775 mL	1.3873 mL	2.7747 mL	13.8735 mL
50 mM	0.1110 mL	0.5549 mL	1.1099 mL	5.5494 mL
100 mM	0.0555 mL	0.2775 mL	0.5549 mL	2.7747 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc