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Desmethoxyyangonin

Name: Desmethoxyyangonin
Brand: TargetMol
SKU: T5S0734
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0734Cas No. 15345-89-8

Alias Desmethoxy yangonin, Demethoxyyangonin, 5,6-Dehydrokavain

1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.

Desmethoxyyangonin

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Purity: 99.61%

Catalog No. T5S0734Alias Desmethoxy yangonin, Demethoxyyangonin, 5,6-DehydrokavainCas No. 15345-89-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$348	In Stock	In Stock
50 mg	$518	-	In Stock
100 mg	$749	-	In Stock
500 mg	$1,570	-	In Stock
1 mL x 10 mM (in DMSO)	$141	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Desmethoxyyangonin AI Summary

Desmethoxyyangonin exhibits diverse bioactivities across various assays and organisms. It demonstrates antiplatelet activity by significantly inhibiting collagen-, ADP-, ristocetin-, and arachidonic acid-induced platelet aggregation in human whole blood, with the strongest effect on arachidonic acid-induced aggregation (100% inhibition at 100 ug/mL). It shows moderate to low cytotoxic and antiproliferative effects on several cell lines, including human PANC1, HT1080, mouse Colon 26-L5 cells, and specific cytotoxicity to mouse MC3T3-E1 and Hepa-1c1c7 cells. In cancer research, Desmethoxyyangonin induces DR5 receptor promoter activity in human DLD1 cells and inhibits NF-kappaB expression in human A549 cells. It also affects various cellular signaling pathways, acting as an enhancer of SMN2 splice variant expression, an inhibitor of ALDH1A1 and HPGD, an activator of Cytochrome P450 3A4, and a modulator of retinoid X receptor alpha, farnesoid X receptor, androgen receptor, peroxisome proliferator-activated receptor delta, Aryl hydrocarbon Receptor, ARE signaling, and human and rat pregnane X receptor pathways. The compound also possesses antitubercular (MIC of 4.0 ug/mL) and broad-spectrum antiprotozoal activity, with notable efficacy against Plasmodium falciparum (IC50 of 13,000.0 nM). It displays herbicidal effects on plants like Echinochloa crus-galli and Lactuca sativa and antifungal activity against fungi such as Hypocrea rufa and Fusarium species. Minimal inhibition of electric eel acetylcholinesterase and horse butyrylcholinesterase reflects its specificity in enzyme targeting. Moreover, Desmethoxyyangonin shows potential osteogenic activity in mouse MC3T3-E1 cells, enhances ALP activity, but also causes cytotoxicity at higher concentrations. Its weak inhibition on protein interactions involving Bcl-xL/Bak and MCL1/Bid proteins suggests limited effectiveness in disrupting these apoptotic pathways. Collectively, these findings highlight the compound's multifaceted bioactivities and potential therapeutic applications, albeit with varying degrees of potency and specificity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.
Synonyms	Desmethoxy yangonin, Demethoxyyangonin, 5,6-Dehydrokavain

Chemical Properties

Molecular Weight	228.24
Formula	C₁₄H₁₂O₃
Cas No.	15345-89-8
Smiles	COc1cc(\C=C\c2ccccc2)oc(=O)c1
Relative Density.	1.18 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (197.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (8.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3814 mL	21.9068 mL	43.8135 mL	219.0676 mL
5 mM	0.8763 mL	4.3814 mL	8.7627 mL	43.8135 mL
10 mM	0.4381 mL	2.1907 mL	4.3814 mL	21.9068 mL
20 mM	0.2191 mL	1.0953 mL	2.1907 mL	10.9534 mL
50 mM	0.0876 mL	0.4381 mL	0.8763 mL	4.3814 mL
100 mM	0.0438 mL	0.2191 mL	0.4381 mL	2.1907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc