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Anti-TFPI2 Antibody (9M220)

😃Good
Catalog No. TMAY-00960
Alias tissue factor pathway inhibitor 2, PP5/TFPI-2, AV000670

Anti-TFPI2 Antibody (9M220) is a Mouse antibody targeting TFPI2. Anti-TFPI2 Antibody (9M220) can be used in ELISA.

Anti-TFPI2 Antibody (9M220)

Anti-TFPI2 Antibody (9M220)

😃Good
Catalog No. TMAY-00960Alias tissue factor pathway inhibitor 2, PP5/TFPI-2, AV000670
Anti-TFPI2 Antibody (9M220) is a Mouse antibody targeting TFPI2. Anti-TFPI2 Antibody (9M220) can be used in ELISA.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-TFPI2 Antibody (9M220) is a Mouse antibody targeting TFPI2. Anti-TFPI2 Antibody (9M220) can be used in ELISA.
Aliastissue factor pathway inhibitor 2, PP5/TFPI-2, AV000670
Ig Type
Monoclonal Mouse IgG1
Clone
9M220
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TFPI2 (rh TFPI2; TMPY-01004; NP_006519.1; Met 1-Lys 213). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human TFPI2 protein (TMPY-01004)
Antigen Species
Human
Biology Area
Serine Proteases and Regulators
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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