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Spermidine trihydrochloride

Name: Spermidine trihydrochloride
Brand: TargetMol
SKU: T5080
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5080Cas No. 334-50-9

Alias Spermidine hydrochloride, 4-Azaoctamethylenediamine trihydrochloride

Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

Spermidine trihydrochloride

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Purity: 99.90%

Catalog No. T5080Alias Spermidine hydrochloride, 4-Azaoctamethylenediamine trihydrochlorideCas No. 334-50-9

Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$65	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
In vivo	In mouse, Spermidine (200 μg) intracerebellar injection (icb), does not alter basal cGMP levels. Spermidine attenuates responses mediated through the NMDA, NMDA-associated glycine receptor and quisqualate receptors. Spermidine is widely distributed in neural and non-neural tissues and has been shown to play a key role in cell differentiation and growth [2].
Synonyms	Spermidine hydrochloride, 4-Azaoctamethylenediamine trihydrochloride

Chemical Properties

Molecular Weight	254.62
Formula	C₇H₂₂Cl₃N₃
Cas No.	334-50-9
Smiles	Cl.Cl.Cl.NCCCCNCCCN
Relative Density.	0.906 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (981.86 mM), Sonication is recommended.

DMSO: 2.55 mg/mL (10.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.9274 mL	19.6371 mL	39.2742 mL	196.3711 mL
5 mM	0.7855 mL	3.9274 mL	7.8548 mL	39.2742 mL
10 mM	0.3927 mL	1.9637 mL	3.9274 mL	19.6371 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1964 mL	0.9819 mL	1.9637 mL	9.8186 mL
50 mM	0.0785 mL	0.3927 mL	0.7855 mL	3.9274 mL
100 mM	0.0393 mL	0.1964 mL	0.3927 mL	1.9637 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc