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Flunarizine

Name: Flunarizine
Brand: TargetMol
SKU: T21392
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21392Cas No. 52468-60-7

Alias Sibelium, Flunarizinum, Flunarizina, Flunarizin

Flunarizine is an orally administered peripheral vasodilator, acting as a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist, exhibiting anti-migraine activity.

Flunarizine

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Catalog No. T21392Alias Sibelium, Flunarizinum, Flunarizina, FlunarizinCas No. 52468-60-7

Flunarizine is an orally administered peripheral vasodilator, acting as a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist, exhibiting anti-migraine activity.

Pack Size	Price	Availability
25 mg	$30	In Stock
50 mg	$42	In Stock
100 mg	$59	In Stock
200 mg	$85	In Stock

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Product Introduction

Bioactivity

Description	Flunarizine is an orally administered peripheral vasodilator, acting as a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist, exhibiting anti-migraine activity.
In vitro	In cultured rat cortical neurons, Flunarizine blocks sodium current (INa) and calcium current (ICa), with half-maximal inhibitory concentrations (IC50) of 0.94 μM and 1.77 μM, respectively [2]. Flunarizine (concentrations 10 μM, 30 μM; exposure time 24 hours) exhibits cytotoxic effects on chromaffin cells [4]. Within the concentration range of 3-10 μM, Flunarizine demonstrates significant cytoprotective effects on chromaffin cells [4].
In vivo	In a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model, preventive administration of Flunarizine (30 mg/kg, intraperitoneal injection) significantly inhibited LPS-induced cell infiltration, protein leakage, and inflammatory cytokine release. Therapeutic administration of flunarizine (30 mg/kg, intraperitoneal injection) also suppressed pulmonary inflammation, but its efficacy was weaker than that of preventive administration [5].
Synonyms	Sibelium, Flunarizinum, Flunarizina, Flunarizin

Chemical Properties

Molecular Weight	404.50
Formula	C₂₆H₂₆F₂N₂
Cas No.	52468-60-7
Relative Density.	1.170 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (197.78 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4722 mL	12.3609 mL	24.7219 mL	123.6094 mL
5 mM	0.4944 mL	2.4722 mL	4.9444 mL	24.7219 mL
10 mM	0.2472 mL	1.2361 mL	2.4722 mL	12.3609 mL
20 mM	0.1236 mL	0.6180 mL	1.2361 mL	6.1805 mL
50 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4722 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2361 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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