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Flunarizine

Name: Flunarizine
Brand: TargetMol
SKU: T21392
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21392Cas No. 52468-60-7

Alias Sibelium, Flunarizinum, Flunarizina, Flunarizin

Flunarizine is an orally administered peripheral vasodilator, acting as a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist, exhibiting anti-migraine activity.

Flunarizine

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Purity: 99.9%

Catalog No. T21392Alias Sibelium, Flunarizinum, Flunarizina, FlunarizinCas No. 52468-60-7

Flunarizine is an orally administered peripheral vasodilator, acting as a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist, exhibiting anti-migraine activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	$42	-	In Stock
100 mg	$59	-	In Stock
200 mg	$85	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.9%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Flunarizine is an orally administered peripheral vasodilator, acting as a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist, exhibiting anti-migraine activity.
In vitro	In cultured rat cortical neurons, Flunarizine blocks sodium current (INa) and calcium current (ICa), with half-maximal inhibitory concentrations (IC50) of 0.94 μM and 1.77 μM, respectively [2]. Flunarizine (concentrations 10 μM, 30 μM; exposure time 24 hours) exhibits cytotoxic effects on chromaffin cells [4]. Within the concentration range of 3-10 μM, Flunarizine demonstrates significant cytoprotective effects on chromaffin cells [4].
In vivo	In a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model, preventive administration of Flunarizine (30 mg/kg, intraperitoneal injection) significantly inhibited LPS-induced cell infiltration, protein leakage, and inflammatory cytokine release. Therapeutic administration of flunarizine (30 mg/kg, intraperitoneal injection) also suppressed pulmonary inflammation, but its efficacy was weaker than that of preventive administration [5].
Synonyms	Sibelium, Flunarizinum, Flunarizina, Flunarizin

Chemical Properties

Molecular Weight	404.50
Formula	C₂₆H₂₆F₂N₂
Cas No.	52468-60-7
Smiles	C(N1CCN(C/C=C/C2=CC=CC=C2)CC1)(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4
Relative Density.	1.170 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (197.78 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4722 mL	12.3609 mL	24.7219 mL	123.6094 mL
5 mM	0.4944 mL	2.4722 mL	4.9444 mL	24.7219 mL
10 mM	0.2472 mL	1.2361 mL	2.4722 mL	12.3609 mL
20 mM	0.1236 mL	0.6180 mL	1.2361 mL	6.1805 mL
50 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4722 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2361 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc