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H-1152

Name: H-1152
Brand: TargetMol
SKU: T7552
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7552Cas No. 451462-58-1

Alias H1152, H 1152

H-1152 is a cell membrane-permeable and selective ROCK (Rho-kinase) inhibitor (Ki=1.6 nM) that increases neurite length in neuron-rich cultures and inhibits MARCKS Ser159 phosphorylation in LPA-stimulated neuronal cells.

H-1152

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Catalog No. T7552Alias H1152, H 1152Cas No. 451462-58-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$43	-	In Stock
1 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	H-1152 is a cell membrane-permeable and selective ROCK (Rho-kinase) inhibitor (Ki=1.6 nM) that increases neurite length in neuron-rich cultures and inhibits MARCKS Ser159 phosphorylation in LPA-stimulated neuronal cells.
Targets&IC50	Src:3.06 μM, AMPK:100 μM, ROCK2:12 nM, PKA:3.03 μM, Abl:7.77 μM, PKC:5.68 μM, MLCK:28.3 μM, GSK3α:60.7 μM, P38α:100 μM, MKK4:16.9 μM, Aurora A:0.745 μM, EGFR:50 μM, CaMK II:0.18 μM, PKG:0.36 μM
In vitro	H-1152 potently inhibits Rho kinase (Ki = 1.6 nM) while exhibiting only mild inhibitory effects on PKA, PKC, and MLCK with Ki values of 0.63 μM, 9.27 μM, and 10.1 μM, respectively. In LPA-treated cells, H-1152 (0.1-10 μM) significantly suppresses MARCKS protein phosphorylation with an IC₅₀ of 2.5 μM, whereas no such pronounced effect was observed in PDBu-treated cells [2]. H-1152 (0.5-10 μM) does not reduce neuronal viability. Neither does H-1152 (1, 5, or 10 μM) alter the proportion of different neuronal morphologies. Furthermore, in both BMP4 and LIF culture systems, H-1152 (10 μM) enhances neurite outgrowth length [3].
Synonyms	H1152, H 1152

Chemical Properties

Molecular Weight	319.42
Formula	C₁₆H₂₁N₃O₂S
Cas No.	451462-58-1
Smiles	S(=O)(=O)(C=1C2=C(C=CC1)C=NC=C2C)N3[C@@H](C)CNCCC3
Relative Density.	1.218 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (250.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (10.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1307 mL	15.6534 mL	31.3067 mL	156.5337 mL
5 mM	0.6261 mL	3.1307 mL	6.2613 mL	31.3067 mL
10 mM	0.3131 mL	1.5653 mL	3.1307 mL	15.6534 mL
20 mM	0.1565 mL	0.7827 mL	1.5653 mL	7.8267 mL
50 mM	0.0626 mL	0.3131 mL	0.6261 mL	3.1307 mL
100 mM	0.0313 mL	0.1565 mL	0.3131 mL	1.5653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc