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Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody 2

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Catalog No. TMAC-00443

Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Siglec-2/CD22 (Tyr807). Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody can be used in WB.

Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody 2

Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody 2

😃Good
Catalog No. TMAC-00443
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Siglec-2/CD22 (Tyr807). Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2167-10 days
100 μL$3187-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Siglec-2/CD22 (Tyr807). Anti-Phospho-Siglec-2/CD22 (Tyr807) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:500-1000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundMediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of tyrosine 807 (G-D-Y(p)-E-N) derived from Human BL-CAM
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 95 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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